Being light at night, common in today's lifestyle, can help spread breast cancer bones, researchers have shown for the first time in animal testing. The results of the research will be presented on Saturday in END 2019, in the New Year of the Endocrine Society in New Orleans.
"Until now, no-one has reported that darkness causes dark cirrhosis, and then breast cancer causes metastatic bone," said Muralidharan Anbalaga, Ph.D., Assistant Professor, Tulane University Medicine New School. Orleana, La … "" It is important that many breast cancer patients may be able to stay up at night at night, due to stress, excess light in the room from mobile devices or from other sources or night shift work. . "
Over 150,000 women in the US had breast cancer in 2017, which was spread out of metastasized or breast-fed breast cancer, according to estimates by the National Cancer Institute. When breast cancer spreads, it often reaches bones, which can lead to severe pain and brittle bone.
In this preliminary study conducted by the Louisiana Research Center Consortium (LCRC) and Tulane Center Biology, the Cancer Research Consortium (LCRC) and the Tulane Center for Circadian Biology, the researchers created a model for seasonal metastatic cancer mice. The positive estrogen receptor was injected into human breast cancer cells with a tendon for growing bones, or shinbone, with a slight tendency toward female mice. Like humans, the mice used in this research produce night-time melatonin in the circadian night-time signal. This night melatonin signals a powerful anti-cancer action and promotes sleep.
Every day, more than 12 hours were kept mice. A team with three mice was in darkness for another 12 hours, which helped them to produce high levels of endogenous melatonin. Another team spent 12 hours light and 12 hours in the evening, melatonin eliminating night-time production. According to Anbalagan, the dark light was 0.2 lux, less than a night-time cell phone or screen light.
X-ray images with light cycles of light and clear light increased larger tumors and bone damage compared to mice with light / dark cycles.
"Our research has identified the importance of anti-malignant signal melatonin in the night circuit.
The main goal of their research, he said, is to find a way to inhibit cancer progression of breast cancer in bone marrow.
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