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Morning ramps in human metabolism, exam shows – ScienceDaily



Fasting will help you lose weight, but new research suggests that you can go without food and promote human metabolic activity, it causes antioxidants and reverses the effects of aging. Scientists from the Science and Technology Institute of the Okinawa Technology Center (OIST) and the Kyoto University identified 30 previously unanswered substances, whose quantity is increasing in circulation and indicates a number of health benefits.

"We are currently investigating aging and metabolism and looking for unknown health effects for human life," said Dr. Takayuki Teruya, first professor of paper and OIST G0 Cell Unit technician, Prof. He heads Mitsuhiro. Yanagida. "Against the original hope, the activation of the induced metabolic activation was activated".

Research published on January 29, 2019 Scientific reportsIt presents a study of total human blood, plasma and red blood. Researchers control the varying levels of metabolites – Substances that are produced by organisms in chemical processes that give energy and grow. The results revealed 44 metabolites, those that were previously unfocused 30, that is to say, between 58 and 60 intermediate subjects between 5 and 60 intermediate cases.

In previous research, the G0 Cell Unit identified different metamorphoses, including age decline amounts, including three leukines, isoleucine and ophthalmic acids. In the lungs individuals, these metabolites increase the level, and the variety suggests a mechanism that can help with greater severity.

"These metabolites are very important for the maintenance of muscles and antioxidants, respectively", said Teruya. "This result suggests a rejuvenation opportunity caused by fasting, so far unknown".

Metabolites Clans Mechanisms and Health Effects

The human body uses carbohydrates to get energy fast – when available. If carbohydrates are starving, the body begins to steal alternative energy stores. The "energy replacement" action evidences a good evidence, that is, metabolites called butyratrates, carnitines and branched amino acids. These well-known energy replacement markers have been proven to accumulate on fast bundles.

But fasting can cause energy-substitutable effects. In the comprehensive study of human blood, the researchers established fast markers and much more. For example, the growth of the cycles cycle cycles has been found, the organism releases the energy storage process that connects carbohydrates, proteins and lipids. The marked increase suggests, in the orchard, the small strengths in each cell become overdrive.

The thrush, gene expression and chemical substances that fulfill essential functions in protein synthesis were also enhanced to improve brain and pyrimidin metabolism. The discovery suggests how fast the protein can be reprogrammed in time, thus changing their function. Changes lead to homeostasis in cells, or they are used to edit their genes expression in environmental impact.

When metabolized, purine and pyrimidine also contribute to the production of antioxidant agents. Several antioxidants, such as ertzelionein and carnosine, were significantly increased during the 58-hour study period. Antioxidants serve to protect free radicals produced during metabolism. The products of a metabolic pathway called "Pentosa phosphate" also have adverse effects of oxidation and, in turn, they increase during fasting, but only in plasma.

Newfound Health Benefits?

The authors suggest that these antioxidant effects are the main body to respond to the bundle because the ice rages promote a dangerous oxidative environment. The exploratory study provides the first proof of antioxidants as a fast marker. In addition, the study presents an innovative notion that vegetables can boost the production of metabolites of many ages, but also in older people.

"Recent aging studies have shown that calorie reduction and the effect of fasting on fast animals in animal models … but the exact mechanism has been a mystery," said Teruya. "Verifying anti-aging effect from different perspectives is possible to develop exercise programs or drugs capable of causing a similar metabolic reaction."

The discovery spread the idea of ​​forgiveness for human health. The next step would be to replicate these studies in a more detailed analysis or to investigate how other modifications would have to undergo metabolic changes.

"People are interested in reducing menstrual effects of metabolic illnesses and prolonging their livelihoods or reducing calories compared to animal models," said Teruya. "The metabolic changes caused by the orchard are expected to retain health wisdom."


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