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New electronic transmission microscope for medical and material research

Credit: Oregon University

Ben McMorran at the University of Oregon's Physics Laboratory was awarded a 2018 pair. Four papers were published in the new life for the transmission of electronic communication microscopes, for medical and material research.

They have created a technique, STEM holography, which differentiates the two paths that send electrons from one sample to the other. This allows you to measure the delay between them to create a high-resolution image. Provides an atomic resolution enhanced by an outer structure of a sample and shows previously unexplored interfaces between a sample and its underlying material.

The researchers have demonstrated the use of gold nanoparticles, carbon substrates and electrical fields. In the end, it could be useful for direct biological samples, said McMorran physics professor associate professor.

"This technique allows us to analyze high-resolution materials, accurately measure and understand better than before," said Fehmi Yasin PhD. "In biomolecular materials atomic resolution we can add images without destroying them? Not yet, but our technique is a good first step".

Researchers from Germany, Japan and the United States 30 years ago made this point possible, but the available technologies did not prove it as a practical image technique, Yasin said. The UO researchers now show through the microscope UO, Lawrence Berkeley National Laboratory and Hitachi Ltd. Japanese Research and Development Group, with STEM Holography.

Electronics is a holographic-based technique that provides a new breakthrough for the resolution of the atomic scale that supplies the most bargain electron bargain, especially built openings and stable power sources.

"With STEM flexible holography, as we developed with Hitachi, Tashiaki Tanigaki, we now have more geometric materials to be more interesting," said Yasin. "Previously, STEM holographic vision may be perhaps 30 nanometers. The use of flexible STEM holography extends the field of vision."

The first electronic transmission microscope was made in Germany in the year 1931 by a physicist, Max Knoll, and an Ernst Ruska physicist. The first commercial version was created in 1939. Ruska Nobel Prize winner in Physics in 1986

Millions of millions of microscopes generate micrographs that pass through an electron glass through a slice of a sample. Traditionally, when transmitting electron microscopes are scanned, the magnetic fields are directed to a beam at the sample atom size. This beam is scanned through a sample, but a large number of electrons are required, because most of them have been diverted by a sample.

The UO approach places a diffraction network over a sample, creating additional hologram samples and a hologram tube. It captures the electron signals that are inserted and some details about what happens through a sample.

The latest paper series combines STEM holography with computer simulation.

Credit: Oregon University

"We have placed an electrospray microscope in the conditions we could control, and we analyzed different types of samples," said former Ph.D. Tyler Harvey, a postdoctoral researcher at Gottingen University. "We also simulated the images of a sample and the simulations match the experiment very well".

In a December paper by Harvey Applied Physical ReviewThe UO team determines how the technique and theoretically works.

In another paper Nano Letters, The Yasin-led team has demonstrated that this technique offers sub-nanometer resolution of basic material with carbon. The color indicates thickness, which adds the third dimension and improves the measurements.

The images were clear with a low number of electrons, the researchers said.

"We believe that STEM holography will be a great tool in the field of science and biology of materials," said Harvey. "The technique really stands out in the images of magnetic and electric fields, which can be used by most scientists in the use of atoms where they are most used."

The ability to use biological species techniques is a long way, but they are likely to make huge payments, Yasin said.

"Today we have a lot of drugs that attack the composition of cancer," said Yasin. "But this composition is similar to our body, so that these cancer drugs attack cells and other cells of the body at the same time. Each atom in cancer cells could have a better and better drug use, lethal side effects."

McMorran wrote for the first time in a hologram vision in January 2011 the role of Science Paper with the National Institute of Standards and Technology of Maryland.

In its OO lab, supported by the National Science Foundation and the US Department of Energy, researchers continue in four areas, all looking for parts of the material that are difficult to detect.

They are four transparent material areas, including biomaterials or other organic molecules. electric fields, such as load and its distribution in a single transistor; Magnetic fields, for example, available on hard drives and potentially spinronic; and electrons and qubits are used in quantum computers.

"Anyone from these things would not work," said McMorran, the Materials Science Institute and member of the Oregon Center for Optical, Molecular and Quantum Science. "There is a better technique to achieve, so we can develop a useful tool to get four or one of them. Right now, all the arrows have four points."

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More information:
Fehmi S Yasin et al. With interferometric interference through the electronic scanning electron microscope, Physics D Magazine: Applied Physics (2018). DOI: 10.1088 / 1361-6463 / aabc47

Fehmi S. Yasin et al. To test atoms of subnanometer resolution: Transmission scan Electronic Holographic Microscope, Nano Letters (2018). DOI: 10.1021 / acs.nanolett.8b03166

Fehmi S. Yasin et al. Analogue interferometer with electron interferometer with amplifier splitter grille beam amplifier, Applied Physics Letters (2018). DOI: 10.1063 / 1.5051380

Tyler R. Harvey et al. Interpreted and Effective Interferometric Contrast With the Beam Splitter, which is scanned through the electronic transmission microscope, Applied Physical Review (2018). DOI: 10.1103 / PhysRevApplied.10.061001

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