Cancer treatment is susceptible to accelerating aging processes in the body. A new study found that the decline in the cognitive function of women who underwent breast cancer treatment has long since been shown by biological aging indicators. Publish online at the beginning CANCERA journal published in the American Cancer Society, the discovery indicates the aging effects of cancer treatments and is linked to cognitive decline.
Breast cancer treatment increases the risk of patients with long-term and late-term toxicity, including permanent nerve, pain and cognitive dysfunction. Even though some treatments, radiation and chemotherapy drugs can damage cancer cells DNA, they can damage normal cell DNA, as it can lead to more rapid biological aging.
Biological aging indicators are related to the cognitive function of breast cancer, Dr. Judith E. Carroll, Associate Professor of Psychiatry, UCLA Center for Psychoneuroimmunology Centers, and the Semel Institute of Neuroscience and Human Behavior, and their colleagues. Breast cancer was treated by 94 female teams three or six years earlier. Biological aging indicators raised DNA damage, reduced telomerase activity in enzyme, and shorter length of telomere in certain blood cells. Telomerase is an important enzyme to keep the length of telomeres, repeats the DNA sequences at the ends of the chromosome, which help to maintain cell health and as a cellular cell marker.)
Women treated with breast cancer had more damaging DNA and telomerase activities that were much lower in performing executable functions. In addition, the activity of the telomerase was lower in terms of attention and speed. Telomere length was not related to neurocognitive domains.
"These findings are important because they provide more information on the treatment of cancer that causes cognitive cancer treatment for cancer, this information can be informed of future research and may involve new interventions to prevent these cognitive concerns," said Dr. Carroll. There is also a UCLA Jonsson Comprehensive Healthcare Center. "Works are novels that identify key factors in biological aging and connect them to cognitive function, which initiates new research paths."
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