Sunday , July 3 2022

Chinese claims of genetically modified children


Hong Kong – A Chinese researcher says they have created the world's first genetically modified babies: two twins, whose DNA changed their future infections with the aim of helping Human Immunodeficiency Virus (HIV) help.

If it's true, science and ethics would be a leap deep.

A scientist from the United States participated in China, but this gene edition is forbidden to change DNA in its country to future generations and damage other genes.

Many conventional scientists believe it is very dangerous to test, because a Chinese report denounced human experimentation.

The researcher at He Jiankui, Shenzhen, said that the emulsions of the couples of seven couples had gone through the reproductive treatments, and so far the pregnancy occurred. He announced that his goal was not to cure or prevent hereditary disease, but to provide a few people with a potential to face a possible future possible infection with HIV, a virus that causes acute immune deficiency syndrome (AIDS).

Parents involved do not identify or interview, and do not say where they live or where they worked.

It has not been ratified by the same Claiming it, and it has not been published in a journal so it can be analyzed by other experts. As reported, Monday was published in Hong Kong, one of the organizers of the international conference on the generation of genes on Tuesday and before the exclusive interview with The Associated Press.

"I feel very sorry, not the first one, but also an example," said the AP. "Society will decide on the next" when it is forbidden or prohibited.

Some scientists were surprised to hear the claim and strongly condemned it.

"It is impossible … that the human experiment is not morally or ethically defensible," said Dr. Kiran Musunuru, expert in genetic editing at the University of Pennsylvania, and a genetic journal editor.

"This is too early," said Dr. Eric Topol, a Scripps Translational Research Institute in California. "We're working on a man's operating guidelines, it's a big problem."

However, Harvard's renowned genetist, George Harvard, defended HIV's genetic editing essay, which he described as "a bigger and greater threat to public health".

"I think that is justifiable," he said.

In recent years, scientists have easily found genes to edit DNA branches that govern the body. The CRISPR-cas9 tool, the DNA, causes problems with the provision or disabling of genes required.

Recently, they have tried to treat deadly diseases among adults and the changes are limited to that person. Sperm, ovule or embryo editing is different, changes may be inherited. In the US, it is not allowed, except for laboratory research. China prohibits human cloning, but not specifically the gene edition.

He Jiankui (HEH JEE & # 39; -an-qway), "JK" speech, he attended US Rice and Stanford colleges. He opened a laboratory in the South China Science and Technology University to return to his home town, where he has two genetic companies.

A US scientist, who worked with this project when he returned to China, was Michael Deem, a physics and bioengineering professor, a Rice consultant at Houston. Deem called "little participation" and is part of the scientific consultancy of both companies.

A Chinese researcher has said he has been practicing for several years in mice, monkeys and human embryos, and has applied for patents in his methods.

He chose to test the embryonic gene's embryo because they are a big problem in China. Disables a gene called CCR5, a virus that causes AIDS, AIDS, to eradicate a protein gateway that allows access to a cell.

All men in the project had HIV and not all women did, but the gene did not prevent the risk of transmission, he said. Parents have tightened their liver medications to their infections, and there are easy ways to prevent infections that do not cause genic mutation.

Instead, it was called upon to offer a couple of HIV-infected couples to have a child that could protect them from a similar child.

He recruited couples through a group of promotional AIDS in Beijing called Baihualin. His leadership, known as "Bai Hua", said AP did not make it uncommon for people with HIV to lose their jobs or reach the doctor by revealing their infections.

That way he got the job:

Genesis edition occurred during IVF or fertilization of the laboratory plaque. First, to separate the sperm from the sperm from the sperm, fluid capable of burying flu. The only sperm is placed in a single ovule to create the embryo. Then the genre editing tool was added.

When the embryos were 3 to 5 days, some cells were removed and the edition was checked. Couples can choose whether to use embryos to edit embryos during pregnancy. In total, 16 of the 22 embryos were published and 11 embryos used six implants to get pregnant, he said.

Evidence suggests that a twin changed copies of two genes and the other twins were altered, without proving any other genes' harm. People with a copy of the gene still remain, but very limited research suggests that their health may slow down slowly.

Several scientists have reviewed the materials provided by the PA and, to date, it has not been sufficient to make an assessment or exclude any damages.

In any case it was not completed, and it seems that a twin, at least, is a mosaic cell with some changes.

"It's almost nothing like editing", "if some cells change, because the HIV infection may still occur, the Church said.

The Church and Musunur questioned the decision to use embryos to be used during a pregnancy, because Chinese researchers said they previously knew that copies of the genes did not change.

"At the child's point, nothing has happened about HIV protection, and it still poses a risk to all the unknown risks of the child," Musunur said.

Using this embryo suggests that the main role of the researchers is "trying to solve the problem, avoiding this disease," said the Church.

Although the edition works well, people with non-CCR5 common genes have a higher risk of hiring other viruses, such as the West Nile, and dying from the flu. According to the muscular, there are many ways to prevent liver disease and if it is very treatable, other health risks are a concern.

There are also questions about what he has said in the future. He made his official commentary on his work, initially, on August 8, when he started a Chinese record of clinical trials.

It is not clear to the participants to understand the purpose and possible risks and benefits. For example, the authorization form called the "AIDS vaccine development program".

Rice scientist, Deem, said the presence of potential participants in China was permitting them and they understood "completely" alleged risks.

Deem said he was working in the He vaccine study that Rice and the genesis edition is similar to that of the vaccine.

"That can be the case as a layman describes," he said.

Two men are physicists and do not have clinical experiments in humans.

Chinese scientist, He, has said personally he has made the goals clear and informed that participants never attempted to edit the embryonic gene and bring risks. In addition, it would also provide coverage of any child-created insurance project and plan a medical check-up if children are 18 years of age or older when they are older.

There is another pregnancy attempt to examine the safety of this study and experts in the field, but the participants did not previously tell them that they did not get the chance to prove their "first" pregnancy, he admits. Multiple fertility treatment was part of the treatment they offered.

She approved and approved her project at the Shenzhen Harmonic Women's and Children's Hospital, and it is not one of four hospitals, given the embryos given her research or pregnancy tests.

Some other hospital staff were obscured about the nature of the research, and according to him, Deem prevented some liver infections.

"We think this is ethical," said Lin Zhitong, director of Harmonicare, head of the ethics panel.

As for doctors who manage HIV samples, he said. Qin Jinzhou's He lab was an embryologist who squeezed sperm from the AP and confirmed that he had injected the genetic edition of pregnancy attempts.

Those who participate in the study are not ethicalists, he said, but "there are so many authorities as to what is wrong, because their lives are on the line".

"I think families and their children will help," he said. If it causes unwanted side effects or damage, "it would be their own pain and it will be my responsibility".

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