Tuesday , June 22 2021

Radical findings can show mitochondrial DNA when it is inherited from Dad



All DNA is not the same, and science has long said that it is not enough to overcome all types of DNA, either from your mother or from your father. But the textbook looks like the time it has rewritten.

While most of our DNA penetrate into the nucleus of the cell, our genetic codes are stored in the mitochondria, called the force of the cell. The conventional approach is inherited from the mother of mitochondrial DNA (or mtDNA), but new evidence suggests that this is not the case.

A new study led by a Taiwanese monger at the Medical Center of the Cincinnati Children's Medical Center shows that human parental inheritance of mitochondrial DNA may begin with the treatment of a four-year-old boy.

The doctors evaluated the signs that children had, fatigue, muscle pain and other symptoms, and they had a mitochondrial disorder that was tested.

When Huang did the tests, then he tried again, he did not return the results.

"That's impossible," said NOVA Next.

Reason Huang was so shocked that a mix of boy results – a heteroplasm called – showed his mitochondrial DNA, and that was more than just his mother's contributions.

While proving the transmission of mother-in-law of other species, the existence of human phenomenon has been debated, but never proved this way.

"It exhorts all genetic-based areas," the Trevor Branch ecologist at the University of Washington did not focus on research, Tweeted About discovery.

When the boys' sisters showed evidence of a heteroplasm, Huang and some researchers analyzed the DNA of the baby's mother DNA. They also showed the same mixture.

This led to the study of mother mtDNA analysis, in which mother mum DNA was divided into 60/40 parts, respectively, from mother and father.

"Our results suggest that even though the central succession of mtDNA motherhood continues to be useful, there are some special cases in which parents of the father-in-law of the baby are passing on to their offspring," the author explained.

But although they may be extraordinary in these cases, they are not as rare as scientists.

In all, researchers showed a high level of multicentre high levels of Heteroplasia with different families of 6 different families (24 to 76 years old), with 17 separate people.

Before that, two cases that occurred early in the century were two mutations that could be proposed as an ADN transmission, but another 16 years passed.

Now, the results were not isolated, and sequencing technologies are increasingly advanced, it gives us a better tool to understand what is going on here and how parenting is actually transmitting mtDNA.

"This is a truly positive finding," the researcher at the Stanford University, Xinnan Wang, did not participate in the study, said NOVA Next.

"A completely new field can be opened … and change the way we look for the cause [certain mitochondrial] illnesses. "

The researchers point out the strength of the first view, that maternal transmission was possible due to technical defects, so far they could be two bipartisan transmissions.

In fact, it may be that they are "clear and provocative evidence" that they propose to study mtDNA options, although maternal transmission is normal.

"It is likely that these results should be agreed that the inheritance of motherhood continues to be completely dominant in the time of evolution and that, at some point, the father's transmission incidents are not detected in the human genetic record," said the group.

"However, this area remains an unprecedented option".

Discoveries have been reported PNAS.


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