Replication is the greatest magic trick of nature. Look closely, and in front of your eyes, you will see two almost inadequate blocks in almost identical copies. Ready
After more than half a century of research in molecular genetics, it would be easy to believe that we have worked heartily, but this is not the case.
Now, by applying state-of-the-art technology, researchers have found crucial details about the DNA magazine's replication.
"It's a pretty mystery," says molecular biologist David Gilbert, from Florida State University.
"The replication seemed exciting to us, everything we confused. We have described it in detail, it shows changes in different types of cells and breaks the disease.
"But we did not know until now that the last piece, the control elements, or the DNA sequences that control it."
Any open textbook on the subject can be found showing charts of deoxyribonucleic acids (DNA), such as the longest circuit, through intelligent chemistry and industrial protein hosts.
Most of us glamorous are delighted with the details of this luxurious generosity, thanks in general to the trick.
But the researchers have shown that the enormous complexity of the process, especially in mammals, has proved to be a revolutionary challenge.
Like magic tricks, times are critical. However, confusion with protein regulators does not seem to be such a bigger difference, if the exact rhythm of the replication indicates that the DNA molecule is related to itself.
Gilbert and his team, together with the technology called CRISPR, wanted to reveal chemical architecture to eliminate chromosomes, apart from these factors.
CRISPR is a molecule tool based on bacterial processes for the identification of antivirus genes. Once the specific genetic code has been detected, the enzymes associated with CRISPR cool and break the sequence by effectively eliminating the threat.
In the hands of researchers, this system can be used to cut any sequence of DNA.
Gilbert used it to channel a variety of structures within the DNA architecture of fertile embryos to change them or completely cut them.
The initial focus was on the CCCTC binding factor (CTCF) in a protein binding site. This protein helps to regulate the whole process of transcription, making the landing area a natural place to locate the main temporal space operations of the DNA.
However, with them tricks had little effect on the real time of replication processes. He had to work something else.
Finding this virtual greeting on a needle would require more than one bad luck.
It was placed as a 3D resolution resolution of the contact centers that make DNA itself. As happened in the hands of a magical workman, the group began to "finger".
Specifically, several keyboards were identified outside the boundary CTFC boundaries. Chaos causing fractures – replication time was eliminated, DNA architecture itself weakened and transcription lost.
"Removing these items, segment replication changed from the beginning to the end of the process," says Gilbert.
"This was for a moment, the only result that your socks blows off."
Their results open a new path to health and pathology research. If the DNA replication time-maker is determined, the researchers may see processes that cause certain illnesses.
"If you duplicate it already in another place and place, you can collect completely different structures," says Gilbert.
Since physicist Erwin Schrödinger announced a "crystalline aperiodic", we have been able to explain a replication of a cell using just a little more than the basic physics of chemistry.
Eight decades later, physics behind molecular genetics are still sharing secrets.
It is not the magic of nature that makes the most amazing show.
This study was published Handheld.