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Scientists predict the efficiency of the transcription factor

Experienced bioengineering experts in the Ecole Polytechnique Fédérale de Lausanne have discovered the transcription factors (TF) to detect the effectiveness of the gene expression in order to regulate gene expression.

The transcription factor is associated with DNAmolekuul_be | Shutterstock

Research findings may determine the control of TF's most effective gene expression patterns and causing the fate of the cell.

Gene transcription is the first step in making proteins and TFs are proteins that regulate this process. DNA and genetic "deactivation" genes that work with specific sequences to "change" sequences.

In addition to joining specific DNA regions, transcription factors are not associated with random random DNA sequences. This non-specific link allows TF to optimize efficiency in specific home-based local connections, allowing it to slide across the ADN.

However, scientists still do not know why more than one hundred people attach more than one hundred cords.

Now, David Suter and colleagues have found that the response has the ability to link the "mythological" chromosome.

Using photopelling and a single molecular image, based on a 501 TF saturation model, the group found that the plasmodic binding chromosomes predict the TF's movement in the nucleus and the effectiveness of locating its cords.

Thanks to the research that combines these experiments, the entire genome TF maps demonstrated that TFs had no ability to specifically link DNA.

The TF related to mitotic chromosomes moved in the nucleus of the movement and was particularly effective in finding the genes needed to regulate gene expression.

Transcription factors can largely change the genomic scanner's ability to link sites, and these differences are predicted by how much they link to the chromosome.

David Suter, Principal Researcher

"The most effective transcription factor in the genetic search could be able to drive major changes in genetic expression patterns, even when expressed in small concentrations, and therefore particularly important for the decision-making of the cellular destiny."


How to transcribe the genome of the factors exploring

The link to the chromosome binds the interface's transcription factor properties. Nature Communications. Jan 2019.

Posted in: Molecular and Structural Biology | Cell Biology | Genomics | Life Sciences News

Labels: Bioengineering, Cell, Chromosome, DNA, Gene, Gene Expression, Genes, Genome, Image, Molecule, Nucleus, Transcription.

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