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Why are you some people left? – 01/30/2019



There are people who can not eat anything without eating, they like it to be pleasant and the body does not like it, while others gain weight easily. Researchers from the University of Cambridge have shown in the United Kingdom that weight gain is more important in genetics.

Overweight and obesity are not aesthetic problems, but also increase the risk of health, diabetes, cardiovascular diseases and certain types of cancer.

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Obviously, in recent years, changes in our environment such as calorie-rich foods and sedentary lifestyles have been boosted by obesity. great individual variation The weight of the population that shares the same environment. Many people seem to like having food and being thin, often causing overweight or unwanted etiquette.

With the support of Wellcome and the European Research Council, Professor Sadaf Farooqi, under the direction of the Wellcome-MRC Center of Science Center of the University of Cambridge, "Study on Slim and Slender Individuals" (STILTS, English Acronym) why and how others It could be overnight.

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Twenty examinations showed that the change in body weight is very important for our genes. To date, studies are aimed at people with excess weight. Among these, hundreds of genes were found that a person is overweight and, sometimes, defective genes can cause severe obesity to childhood.

The Farooqi teacher group has collected 2,000 masses of people (body mass index – IMC – less than 18 kg / m2) but healthy, medical conditions or eating disorders. They worked in the UK's general practice, to study saliva samples to enable DNA analysis and respond to questions about health and general lifestyle. That is what you think It is the only cohort in the world and scientists have emphasized the fact that the National Institute for the Health Research of the United Kingdom, the National Health Service Research Infrastructures, admitted, and contributed a lot to the research.

In the research published in the PLOS Genetics journal, Farooqi lecturer, Dr. Ines Barroso, helped the Wellcome Sanger Institute. Compare up to 14,000 people with DNA: 1.622 STILTS team volunteers; In 1985, people with severe obesity and more than 10,433 normal weight control.

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Our DNA consists of basic pairs that are represented by pairs A, C, G and T. The chain of these pairs of constituents form genetic regions (which are formed or formed by the genes). Genes explains how our body works, and spelling changes, for example, can have a C instead of A Subtle or sometimes dramatic changes hair color and eye color, as well as weight of a person.

Genetic risk point

The group has found several genetic variants that identify the role played by obesity. They also found it New genetic regions are experiencing severe obesity and some healthy delicacies. Regarding the weight of these genes, scientists have added several variants to calculate the genetic risk score.

"We found obesity The highest genetic risk, more than punctuation in people with normal weight, leads to a risk of overweight. Genetic data is charged against them"says Dr Barroso.

Importantly, the team also showed that the thin had a much lower genetic risk; They show less variants, as we all know, to be overweight.

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"It shows this research for the first time thin and healthy people are often thin, because the genes are less likely to improve people's chances of being overweight not because they are morally higherAs people suggest, says Farooqi lecturer. People often struggle and criticize their weight easily, but science shows things are much more complex. Our weight control is much less than what we think. "

Three of four people (74%) are presented in the STILTS cohort Thin and healthy family, and some of the genes were found to be much more common in groups. In this way, genes and biological mechanisms can be identified to accelerate these people.

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"We already know that people can be for different reasons," says Farooq, "people do not care about food, They can eat everyone else, but never gain weight. If there are genes that prevent weight gain, these genes will be able to face weight loss strategies and help people who do not benefit. "

(Source: DPA)


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