The researchers cause side effects with cortisone preparations
While cortisone is also widely used in many diseases, it also causes unwanted side effects, including metabolism. Why is this now explained by an international research team?
Drugs for many applications
Cortisone is prescribed by various medical conditions. Often inflammation and allergic reactions are used. Among other things, skin diseases, rheumatism, asthma bonchiale, intestinal diseases or multiple sclerosis are also used. Even with any other drug-free application, many patients have reservations or fears of anti-cortical effects. Researchers should now be able to produce some adverse effects with cortisone preparations.
Side effects on metabolism
Inflammatory bowel steroids in long-term patients may cause side effects in metabolism.
Researchers Helmholtz Zentrum München and Ludwig-Maximilians-Universität München (LMU), members of the German Center for Diabetes Research (DZD), have today clarified a mechanism for international partners, called steroids diabetics.
The results are published in "Nature Communications".
"Glucocorticoids, such as cortisone decades, have been used to treat inflammatory diseases, such as asthma or rheumatism, and are the best training for anti-inflammatory treatments," explained Prof. Dr. Med. In a message by Henriette Uhlenhaut.
"But autoimmune diseases, organ transplants or cancer are also used," says Helmholtz Zentrum München (IDO) and LMU Gene Center, head of the Diabetes and Obesity Institute.
"Depending on the budget, one and a half percent of people in the Western world are treated with it, now more than one million German people will participate."
However, their variability is limited by certain side effects that occur during therapy. These have negative effects on metabolism.
After the glucocorticoids have been forced into the cellular bodies, many genes are activated and deactivated.
"This has several metabolic genes, which is why the so-called steroids diabetes," explains Henriette Uhlenhaut.
New therapeutic interventions
At this time, his team, at the Salk Institute in Berlin and at the Max Delbrück Center for Molecular Medicine at the Max Delbrück Center in Freiburg, investigated specific mechanisms that link steroids.
"We especially had a transcription factor of E47, which offers modified gene activities in addition to the glucocorticoid receptors, especially in the liver cells," says Dr. Charlotte Hemmer, IDOn and current author.
"We have been able to work on this genome-wide analysis and genetic experiments".
In order to ensure the discovery, scientists also studied the preclinical relationship.
"In fact, in this case the E47 deficiency is protected against harmful effects of glucocorticoids, while the whole E47 steroid administration is linked to metabolic changes such as hypoglycaemia, high blood lipid or liver fat," said Charlotte Hemmer.
Although the components of the recently discovered mechanism are also in humans, Uhlenhaut and his team, together with clinical partners, will want to know in the future that the results will be confirmed.
"In this case, new therapeutic interventions could be offered to make the side effects of steroid therapy more safe for immunosuppressants," says Henriette Uhlenhaut. (Ad)