Thursday , February 25 2021

A Crunching Protein – ScienceDaily

Asymmetry biology is very important in each scale: think of the DNA spirals, the human heart is left-handed, the priority to use our left or right hand … The Valrose Institute's Institute of Biology Institute (CNRS) / Inserm / Université Côte d & # 39; Azur), University of Pennsylvania In co-operation with colleagues, it explains how a single protein influences a spiral movement in another molecule. By means of a domain effect, cells, organs and, in general, the entire body is rotated, causing a lateralized stance. This research is published in the journal Science November 23, 2018

Our world is fundamentally asymmetric: you think that the double strand of the DNA, the asymmetrical division of the end of the cell, or the human heart is located on the left … But how are these asymmetries that are intertwined?

At the Valrose Biology Institute, a research team led by Stéphane Noselli, researchers Inserm and Université Cote d 'Azur, have been studying for right-wing left asymmetries for several years to solve these enigmas. Biologists control the first asymmetry of a gene in common fruit flies (Drosophila), one of the best organic biologists. Recently, the team has demonstrated that the gene plays a role in vertebrates: the protein that produces it, Myosin 1D, controls the rotation of the organs in the same direction or rotation.

In this new study, the researchers produce the Myosin 1D production normally in a symmetrical Drosophila organ, such as the respiratory tract. It was quite impressive enough to promote asymmetry at all levels: deformed cells, circulating around the track, twisting the entire body and locomotive helicopters behavior among larva larvae. Successfully, these new asymmetries are always in the same direction.

To identify the origin of these effects of calcium, the project was also aided by the biochemist at the University of Pennsylvania: on the glass lid, Myosin 1D was contacted by the component of the cytoskeleton (the "spinal" cell), that is, actin. They saw that the interactions between proteins could have an effect.

In addition to the role of the left-wing asymmetric right of Drosophila and vertebrates, Myosin 1D appears as a single protein that can cause asymmetries in its entirety and on all scales, at the first molecule level, then through a domino effect, cell, tissue and behavior level. These results suggest a sudden sudden mechanism of the new morphological features due to the evolution of evolution, such as twisting snails. Myosin 1D seems to have the necessary features for the creation of innovation, as it expresses the expression only by twisting it on all scales.

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