Saturday , January 16 2021

Analysis: New CRISPR-based technology to control pests with accurately guided genetics. – (details)



Using CRISPR gene editing tools, Nikolay Kandul, Omar Akbari, and UC San Diego and UC Berkeley's colleagues invented a method to change the gene's genes that control insect sex and fertility.

Description of the new sterilization technique for decoration-directed insects, or pgSIT, published on January 8, in the journal Nature Communications.

When the PgSIT derivative eggs are introduced into targeted populations, researchers report male male antigens, an innovative method for pest control in the future, environmentally friendly and low cost.

"CRISPR technology has strengthened our team in the development and use of new, innovative, effective, specific, self-limiting, safe and scalable new genetic control technologies for genetic population," said Akba, UC San Diego's Division of Biological Sciences Division assistant "In the future, we believe that this technology will be safely used in the field, in order to eradicate the destruction of target species and eliminate them as well, how to manage insects and control them forward."

Since 1930, some research methods have been used by agricultural researchers to make wild sterile insects wild, controlling and eradicating pests. In the 1950s, a man-irradiated method was introduced in the United States to eliminate New World Screwworm sprouting pests, for animal consumption and livestock damage. These radiation-based methods were later used in Mexico and Central America and continue today.

Instead of radiation, Kandul and Akbari developed Drosophila nuts in the pgSIT (guided precision sterile insect technique) over the last few years, CRISPR uses paralyzing interfering with the key genes that control female viability in pest infections. pgSIT, researchers say, men's results from antiquity have a 100% efficiency. Because the target genes are aware of a broad cross section of insects, researchers may well apply a variety of insect technology, including mosquito propagation mosquitoes.

Researchers see a system of eggs from the species of genetically modified and produced scientists. Eggs are moved to a place where ice is almost full and avoiding the need for a production facility. When eggs are poured into freezing place, the researchers have said that men should have newborn babies with wild females and not be able to produce offspring and drive the population down.

"This is an innovative curve of the very old technology," said Kandul, a scientific project contributing to the Division of Biological Sciences UC San Diego. "This new screw works from one species to another from a portable species, assuming mosquitoes or agricultural pest populations, for example, who eat valuable grapes."

The "gene unit" that constantly absorbs new technologies distinguish generational changes. Instead, pgSIT is considered a "dead end" male sterility closing doors in future generations.

"Sterile insect technique is a safe and proven environment for the environment," the researchers note on paper. "We wanted to develop a non-invasive, safe, controllable and non-invasive genetic technology based on CRISPR, which could be transferred to species in the short term to address forests around the world."

With pgSIT proven by Pegasus, scientists want to develop Aedes aegypti technology, a mosquito that is responsible for transmitting dengue, fever, yellow fever, and other millions of diseases.

"This work can spread the spread of other insect pests to help prevent humanity's plague and to face various diseases of the glasses of the world of agriculture," said Global Director of Suresh Subramani Tata Institute for Genetics and Society.

The paper boxes are UC San Diego and Hector Sanchez C., Sean Wu and John Marshall, UC Berkeley's Junru Liu.


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