Wednesday , October 27 2021

Determining the sex of the newly born geneticist Melbourne



The medical researchers at the Melbourne Murdoch Children's Research Institute have made a new finding about the determination of the sex of the child: XY is not only a chromosome, but a "regulator" is created that increases or reduces the activity of the genes that decide to make men. female

"The elimination of the upward revision of male sex reversal or SOX9" has been published in the journal Nature Communications. The MCRI researcher and PhD student at the Hudson Institute, Brittany Croft, is the first writer.

"The sex of a child is designed based on the creation of its chromosome. The embryo with two X chromosomes becomes a girl, and an embryo from a X-Y is a boy," said Croft.

"Y chromosomes carry a critical gene called SRX, that is, it performs a gene called SOX9 to begin the development of the testosterone in the embryo. SoX9 requires high levels of testis for normal development.

"However, if there is a rupture of SOX9 activity and only small levels, it is not due to a baby that will cause sexual disorder."

The principal author of Andrew Sinclair, said 90% of the DNA was called "DNA rubbish or dark matter," because the gene did not make important gene regulators or reduce the activity.

"These regulatory segments of DNA are called reinforcements," he said. If these potency controlling the testis genes are broken, it can create a baby that causes sexual development disorders. "

Professor Sinclair, a member of the Melbourne University Pediatric Department, said that this study was intended to understand the SOX9 gene regulating improvements and improvements in sexual intercourse.

"We found better tools, together with the SOX9 gene on the high level of XY embryo, to develop normal testosterone and male development," he said.

"Most importantly, XX patients typically had ovaries and were female, but they produced extra copies of these enhancements (SOX9 high levels) and testicles. In addition, XY patients found SOX9 enhancements (low), SOX9 levels, and ovaries instead of testes instead. "

Ms Croft's human gender reversal has shown that, in these cases, the gain or loss of these vital forces that regulate SOX9 gene has been seen; For this reason, these three improvements require normal testing and male development. "

"This research is important because the researchers have only seen genes for the diagnosis of these patients, but we have proved that they should look at non-genetic reinforcements," said Croft.

Professor Sinclair said that about a million of the millions of heats were used to monitor approximately 22,000 genes around the human genome.

"These supplements are on top of DNA, but the genes are away, in earlier regions that refer to ADN rubbish or dark matter," he said. "We can find the key to diagnosing different disorders that are misunderstood in our abilities of DNA."

Source link