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Fertility industry IVF drugs are safe; worry about critics abuse



"I felt my inner bust as my stomach felt," recalled Andreotta.

This was an ovarian hyperstimulation syndrome – a short OHSS – a serious complication that describes a very rare United States fertility industry. However, the long-term security that increases the hormonal strength of OHSS's incidence and fertility continues to be a major issue for the debate, even though the clinic has been a million dollar industrial service for hundreds of thousands of years.

Industry critics believe regulators are over-exulted if they overcome drugs, overcoming potential risks and failing to solve problems. A recently published study, for example, tortures "increasingly aggressive treatment protocols" for OHSS incidents, while others most are "inevitable".

Some researchers have theorized that in addition to OHSS, medication can also cause heart disease, depression, endocrine disorders, cancer, and other conditions. Some of the published studies are conflicting or inconclusive. Unlike many developed countries, with the healthcare provided by the government, the United States does not make any effort to monitor healthcare benefits in fertility treatments.

"All fertility physicians report a fertility patient," There is no known risk. "Well, there is no danger, because nobody looked at it," said Diane Tober, a medical anthropologist at the University of California, San Francisco, reproductive technology what he looks at

The advocates of the industry have indicated that more than 8 million children have been born throughout the IVF and other fertility treatments worldwide, since the first "test-tube baby" reached 40 years ago. Alan Penzias, Associate Professor of Harvard Medical School, has led the Board of Commissions of the American Society for Reproductive Medicine (ASRM), said "reasonably calmed" that drugs do not indicate long-term health threats to health.

"We are currently in the era, there were a lot of things, as we saw today," said Penzias, a Boston FBI surgical director. "Fortunately we did not see anything."

OHSS is an exception. As the most serious and immediate complication of fertility treatment, it can strike a medication that boosts ovaries in multiple eggs, egg freezing, in vitro fertilization (IVF) and a basic donation of egg donations that occur 240,000 times a year.

Strategies to identify and treat high risk patients have advanced in recent years. ASRM, most of the United States clinics, are called OHSS, a "rare but serious complication" that occurs from 1 to 5 percent of the cycles moderately or severely. Fertility doctors often mention that severe OHSS occurs in 0.03 percent per cent.

Penzias has said that OHSS hospitalization has "not been heard today" more than 20 years ago. However, Washington Post has found that there are significant numbers of emergency data in the United States. More than 9,000 women sought help from OHSS hospitals, between 2006 and 2014, the year's most current yearly statistics, about 1,000 women per year.

In Sweden, Canada and Britain – governments in countries that govern governments and monitor patient outcomes – medecines associations say that at least the patients cause at least OHSS symptoms.

This year, the UK's independent fertility regulators, the Human Reproduction and Embryology Authority, discussed the dissatisfaction of OHSS cases reported by fertility clinics, and most of the foreigners who were admitted to hospital admission data. The Watchdog group was not evidence of systematic discovery systems, the clinic clinic audit announced, and "significant questions and questions about the safety of IVF patients" stand out.

Geeta Nargund, a British fertility expert, invites the Parliament to the Parliamentary Assembly to review IVF drug and dosage monitoring requirements and link IVF treatment records to hospital records to better control adverse reactions.

"Now I feel more in love," said Nargund. "It is very important that we do not have healthy women due to IVF treatment".

The known borders are rare, but they are still difficult, public health officials say. When ovals are excessive, the body creates excessive fluid that can close the living organs causing serious problems.

In a major 2005 event, Temilola Akinbolagbe, 33, soon fell to the London bus stop after starting the IVF drug. The fluid that generated OHSS resulted in a clot in the pelvis line and ultimately heart attack.

The cause of death appeared "wrong" – as a voluntary voluntary risk. In most cases, a category that applies to women with excessive illnesses and blue moon cases, for example, as deaths are considered dead.

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& # 39; Wonder drugs & # 39;

When stimulating drugs were marketed at the end of the 1960s, they were named "strangest drugs" and initially boosted ovulation of women who could not produce eggs. During that time, the first commercial fertility clinic in Norfolk, Virginia, was inaugurated, the doctors found that drugs could be much more aggressive.

Usually, a single egg burns the ovules of a woman per month and enters the uterus. Some of these eggs turn into babies; The rest are somehow abnormal or faulty.

Collecting an egg at the same time would not be possible for IVF. Therefore, the drugs are calibrated to activate a series of eggs, if necessary, from 10 to 15 years, according to recent studies. Less and the chance of having a baby a baby goes down. It could endanger the health of other women.

Explain what and how much medication you use delicate, however. Due to the fact that IVF can have a cost of $ 15,000 and $ 30,000, physicians and patients often pressure a large amount of egg.

The fertility group has developed standard regulating doses, but each protocol must be personalized for women's health and size. In the meantime, there is nothing left to stop for doctors who want to use more doses, and there is no systemic method for doses or results.

Specialists have long argued that the short explosion of estrogen, usually in IVF 10 days, has a long-term effect on a woman's body. Researchers have argued for research, emphasizing that estrogen is known to promote certain cancers.

In 2003, it was largely academic debate in the public alarm, Jessica Grace Wing, Stanford University graduate and three-hour egg donor, who had metastatic cancer of the colon at the age of 32. Wing's mother, Jennifer Schneider, the Congress and the United States began to pay more funding to investigate laws and complications that require better monitoring of fertility patients.

"As a scientist, I can not say 100 percent I am sure that fertility drugs" caused cancer, Schneider said in an interview. "I can all say that there is another reason for colon cancer to be so young."

Schneider also published parts published in medical journals by the attention of foreign researchers. Large studies started soon, with 50,000 women donating fertility in Denmark and 24,000 in Sweden. The study did not show the link between drugs and obario cancer.

The latest data, which was presented in a European congress in June, did not show too much risk of ovarian cancer. A study published in July did not support two major cancer wounds and breast implants, 250,000 British women with fertility treatment.

The current ASRM guidelines have stated that "there is no significant additional risk" based on "available data" for invasive obesity, breast or endometrial cancer for fertile fertility. In the case of basic tumors, the groups recognize that "several studies have shown greater risks".

Guidelines do not refer to colon cancer, because there is no consensus. Published in a Netherlands study published in 2016, "confidentially," the researchers said, women with non-IVF do not have a higher risk of colon cancer compared to the general population. However, IVF patients may be nearly twice as likely to develop colon cancer, non-IVF fertility treatments, such as tuberculosis or internal insemination insemination, and researchers suggest "more research is guaranteed."

Schneider shows a tendency to distinguish women from different types of non-proliferative reproductive drugs. Some are sterile, some are fertile but are treated by partners, and some are optional egg freezers and egg donors. Schneider argues that these populations are separate and very different from the levels of age and hormones.

"The results are confusing in the treatment of fertility because women are a diverse group of people," said Schneider, who has no research, exclusively focusing on egg donation and egg donors.

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Organ pipes

Unlike cancer, the relationship between fertility and OHSS is questioned. Complaints about this requirement are filled with fertility blogs and online help groups.

In interviews, about a dozen OHSS described symptom and chaos of the disease when symptoms began. Most people had never heard ovarian hyperstimulation syndrome before being sick.

Asya Ulanova, 22, a donor from New York said that she was watching TV in the middle of November, when she felt a "sock" in her stomach and breathed problems. An emergency room doctor told her that she was a buildup of her stomach fluid and that her medicine had constipation. Later Ulazar only learned that he was suffering from OHSS.

Emily Law, 34, Pensacola, Florida businessman preparing for the IVF in 2014, earned 22 kilos for 48 hours. He died and spent eight days in the hospital, with a stomach tube, to dry the fluid.

"Looking back, I did not know what a terrifying situation was," said Law, who learned how to have twin twin babies.

Logan Andreotta said her medical fertility described the risk of OHSS "ridiculously low". As a result, he was "not mentally prepared" when he woke up in the morning to find out about pushing his abdomen in 2014, suddenly, he was 20 weeks pregnant.

Andreotta went to the fertility clinic, a doctor used a huge needle to enter the "stomach" stomach.

"It was a liter and a liter, and it was like the Coca-Cola you buy at the store – a reddish-brown liquid," he recalled.

On the first day they filled four and five bottles. Two or three more were completed in the next visits. Andreotta said his recovery lasted nearly four weeks.

In spite of being a remote experience, Andreotta, nowadays, at age 29 said she did not refuse to take medication. Of the 50 eggs recovered from the ovary, four are usually tested. One was a daughter, Bonnie, now 4. Two years ago, she won a sister Bonnie, Audrey was invented without IVF.

But Andreot said that other women take fertility medications to denounce all common symptoms.

"I feel super lucky," he said. "I hope they say it could be literally dead."

– – –

& # 39; Echo & # 39; effects

At the beginning of the 2000s, so many women appeared in hospital emergency rooms, excessive fluctuations and congestive heart failure or other diseases related to other organs, which was the responsibility of Jacob Udell, a Canadian medical practitioner.

"We were discredited. They did not have a lot of risk factors, but common issues were achieved with fertility medications," Udell said. "They were receiving high doses and trying to get pregnant."

Udell and her colleagues asked that ER patients might "be the tip of the iceberg" or that reproductive drugs could cause the highest levels of estrogen to cause blood glucose. Water extracted from respiratory blood vessels may explode in OHSS fluid construction. Can the heart be damaged too?

One study, Swedish, indeed. High stroke amongst hypertension and fertility patients. But Canadian studies in a similar design did not have a connection.

So, Udell, now Assistant Professor of Medicine, has been created at the University of Toronto, Natalie Dayan at McGill University, Montreal, for the analysis of fertility and cardiovascular association.

The American Journal of the College of Cardiology published last year, analyzed 42,000 fertility patients. While the treatments did not endanger cardiac insufficiency, the stroke was compromised but not statistically significant.

Udell said that it is impossible to differentiate between fertility drugs or women's fertility problems, age or other factors.

The results, he said, stressed that fertility patients need to be much closer.

"It may not be a special catastrophe of disease," but "it may be long term," said Udell.

"Sometimes after pregnancy everyone becomes a child, but perhaps the mother should also think".

This article was written by Ariana Eunjung Cha, The Washington Post Reporter. Post Dan Keating contributed to this report.


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