Our chromosome tips have structures called telomeres. These structures can be compared to the end of the stem with plastic covers. They work as a protective layer to prevent and distort our genetic material. When they do not work properly, the telomeres can lead to the total erosion of genetic material and can cause cancer and age diseases. Now published in a study EMBO MagazineA group of researchers from the Gulbenkian de Ciencia Institute (IGC; Portugal), led by Jose Escandell and Miguel Godinho Ferreira, discovered a fundamental aspect of telomere regulation.
The human syndromes attributed to flexible telomeres are becoming increasingly common. One of these diseases was identified as a malfunction of a protein complex known as CST, which is responsible for maintaining telomeres. In these complexities, the deficiency creates a telomeropathy called Coats Plus. Syndrome is inherited genetically and contains anomalies of the gastrointestinal system, bones, brain and other parts of the body. The work of IGC researchers now regulates the component "S" of this complex CST. Researchers have found that STN1 (the protein component S) regulates a chemical change that incorporates phosphorus in this protein, and that an enzyme can be a reversed SSU72 phosphatase. Thus, it regulates telomere dubbing and telomerase, enzymes that stretch telomeres.
Researchers have also shown that the process is the same in both yeast and human cells. This means that the regulation of the "S" component remains in the evolution of the species and, in some ways, shows the importance of this process in order to achieve the proper functioning of the cell. It opens up new therapies that are capable of dealing with debilitating illnesses associated with telomeres defects. "The predicted role of this evolutionary phosphorylate evokes the regulation of the cell cycle, phosphatases that save kinasa role, only once in the cell cycle," says researcher Miguel Godinho Ferreira. "With this work, we understand better how telomeres regulation works, the key to cancer and aging," says José Escandell, the first publisher.
Gulbenkian Institute of Science. .