Monday , October 18 2021

Opioids offer chronically low chronic benefits that last a long time. According to studies


These celebrations diminish over time and are at risk of side effects, such as vomiting and constipation, according to a review of nearly 100 randomized trials published in the American Medical Association. Down the line, risks can be physical dependence and overdose.

"The benefits of chronic opioid pain management continue to be quite modest," said Jason Busse, researcher at the McMaster University Medical School Anesthesia Department, Ontario, Canada.

The study's analysis subgroups suggest that alternative opioids (NSAIDs, some antidepressants, and medical cannabis) offer similar benefits to opioids. But his evidence is not so strong, Busse said.

Analysis by federal agencies and other officials in the past years has been prescribing opioids, recognized as an important tool for pain management and access to physical dependence and addiction.

In 2016, the United Nations Center for Disease Control and Prevention provided guidelines for physicians to prescribe more prescription medication more frequently by chronic pain. Busse said that the CDC report set control controls for large-scale analog analysis; After completing the follow-up of the patients, they were missing at least one year.

"We have seen a lot of complementary evidence that has not been taken into account by the CDC guidelines," he said.

Dr. Jianguo Cheng, president of the American Academy of Medical Medicine, said that new analyzes reinforce conventional wisdom amongst specialists. There was no participation in the study.

"We need to try a few dangerous drugs in the first place, so opioids [are] It is not the first line of treatment in most cases, "said Cheng, director of the multidisciplinary Pain Medical Scholarship Program at the Cleveland Clinic." It is not the second line of treatment, and it may not be a third line of treatment. "

The CDC describes chronic pain with "duration of 3 months or normal tissue healing". It is one of the main causes of medical care in the United States, more than 20% of adults (about 50 million people) in 2016, according to a report this year. The other number estimates are double.

"The population of the population is very complex and diverse," said Cheng, who has suffered from injuries, who have lived with multiple surgeries or with disability.

It is distinguished by other types of pain, such as acute pain and cancer. In the end, Cheng said, the use of opioids is less controversial.

Most of these patients will not see significant improvement, however, but not to exclude the subset they live on, Busse said.

"Problematic Interpretation [the study findings] Opioids do not offer significant pain, "he said." With this interpretation, the challenge is that every patient gets pain relief. "

History of Opioid:

His research explains how many chronic pain patients have to treat the doctor to achieve significant improvements: there will be roughly eight patients to obtain pain. In terms of physical function, there are 12 patients. To sleep quality, 17 patients.

And this is the "best case," published by a publisher published in the same journal, by PhD in the Department of Anesthesiology and Criticism at the University of Pennsylvania.

The studies examined in the study largely excluded patients with past or present disorders, and Busse was described as "choosing patients who would be better prognostically." Almost half of their studies were excluded from patients diagnosed or treated with mental illness.

In the three quarters of the analysis, he financed the pharmaceutical industry. The study says Other research shows that industrial-financed research results in better results in many areas.
In recent years, pharmaceutical drugs have sparked fires for medications to market opioids. At the beginning of the 2000s, opioids were seen as a shock as a drug, and doctors dying to face the attack. Former general surgeon wrote in a letter written by Vivek Murthy that the doctors who were not addicted to these drugs were "ill pain". Multiple studies have shown that it is false.
The 2013 study shows that sudden five patients get prescribed opioids where noncancer is acute or chronic.
Other studies last year CDC and other health experts encouraged chronic patients to influence patients with opioids so that they can have a better quality of life. But Cheng should do great care and perhaps do not do any work for all patients, and they add: "I've seen a lot of abandoned doctors and they can not handle people."

According to Cheng, many alternative treatments (such as physical and cognitive therapy) may be available to many patients, in some cases, because insurance does not return.

However, although chronic pain is a source of knowledge, experts say that opioids are part of this arsenal, although risks and benefits are better understood.

"For people who suffer daily chronic dangers of life, if you have tried other alternatives that have not worked, in some cases they can still decide to start trial [opioid] therapy, "said Buss," and now they have evidence that they have the opportunity to get meaningful preferences. "

CNN's Nadia Kounang helped her with this report.

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