Wednesday , May 18 2022

Researchers have found an effective new goal to boost brain stimulation



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Researchers have found an efficient brain function for electrical stimulation to improve the mood of depressed people. As reported in the journal Current biology On November 29, the orbitofrontal cortex (OFC) called the stimulation of the brain region reliably led to an acute improvement in patients with early depression.

These influences did not appear in patients without symptom of the humor, the brain estimates that it works to normalize activity related to neuronal brain circuits, researchers said.

Stimulation was a model of the brain activity model linked to OFC, which was similar to the changing situations experienced by the patients naturally. Our findings suggest that the OFC is a new stimulation target for treating mood disorders. "

Vikram Rao, University of California, San Francisco

The team led by Rao and Kristin Sellers analyzed 25 patients in the Edward Chang laboratory, patients with epilepsy, electrodes placed in the brain for medical reasons, and determine their origin of seizures. Many of these patients also suffered from depression, that is, people with epilepsy often see it. With the consent of patients, Chang's group used electrodes to support small brain electrons to participate in regulating mood areas.

Previous studies have explored deep brain stimulation (DBS) for mood disorders, but their success is critically based on selection. The targets aimed at other mood areas in the brain were not a reliable improvement.

In the new study, the researchers paid special attention to the electrical stimulation of OFC. OFC is a key hub for mood circuits. However, it is one of the least understood brain regions.

"Although OFC's goal is even more intense, it shares a rich connection that connects brain regions involved in emotional processing," Sellers says. A relatively small area of ​​the brain was an attractive target for therapeutic stimulation.

The researchers used electroplated electrodes to accelerate the OFC and other regions, including verbal mood reports and questionnaires. Research found that the unconditional side-by-side OFC stimulation improves the dependence of dependent doses in patients with moderate depression. Changes in brain activity are closely researched by researchers after the stimuli.

The discovery shows that humor in a relatively small brain area can improve electrical stimulation better, the researchers say. Additionally, mood disorders are the result of dysfunction in brain circuits.

The researchers say that he continues working to get DBS into practice in clinical practice. Chang's team is currently exploring the OFC stimulation creates a long-term permanent improvement. They also expect the development of a medical device, patients with treatment-resistant mood disorders, to monitor the development activity of the OFC only and only to stimulate healthy activity within the range necessary.

After all, it would be ideal for normalizing activity indefinitely in mood-related brain circuits without having to do anything for the patient. "

Vikram Rao

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