Wednesday , January 26 2022

Scientists call for more diversity in Genomic Research


Greater genomic research has created important human and behavioral discoveries, but new research at the University of Oxford suggests that scientific progress is lacking in diversity. The people surveyed in the genetic research finds that it continues to be the biggest downturn in Europe, but for the first time it is shown that subjects in a few countries (United Kingdom, United States and Iceland) have specific demographic characteristics. The authors point out that the lack of diversity has significant consequences for the understanding and application of genetic findings.

Research published Communication Biology This helps to understand many aspects that eliminate biomedicine. The work analyzed 4,000 scientific researches between 2005 and 2018, the commissioner of the NHGRI-EBI GWAS catalog, which is currently the Association of Genetics Studies (GWAS).

These studies have identified several genetic-related genetic disorders, such as type 2 diabetes, Alzheimer's, psychiatric disorders, physical behavior, behavior and psychology. The study analyzed the study of the number of genetic associations studied, the number and strength, and the growth and change in the number of results (or "phenotype") studied. He also observed the background, geographic location and demographics, as well as research, including researcher networks and features.

Despite the growth in the growth of the sample dimensions, the genetic findings and genetic discoveries of the characteristics and diseases that investigated the results of the research show that multiculturalism has stopped and that white groups are not underestimated.

As it explodes in this field of research, this has changed dramatically over time, and when non-European ancestors enter the group, they are often the only anti-discovery genetic discoveries that are "replicated". Beyond ancient pluralism, authors are estimated, for the first time, (often repeatedly used) by 72% of the people recognized by third countries; United Kingdom (40%), USA (19%) and Iceland (12%). Data was not only from geographical concentration, but also from older people, women and more important data, as well as greater socioeconomic status and better health.

Professor Melinda Mills (MBE FBA), principal author and professor at Nuffield Sociology, said: "The lack of diversity diversity in genomic research has been a constant concern, but they have paid special attention to the geographic and demographic characteristics of people. Learned, who learned and studied genetic findings. They offer exciting medical options, but without increasing the diversity of the people they are studying and increasing their living environments, the use and returns of this research are limited, which are complex genes and environmental interactions (or, in other words, nature and food), but The findings are very similar, with limited environmental variation. "

The authors also analyzed fundamental founders of this work (especially in the United States and United States sources) and revealed gender differences in the scientific author, who estimated that 70 percent of the authors of the senior author were men. They also provide evidence of a strong core network of data access providers, such as senior researchers in longitudinal cohorts and major biopharmaceutical companies. Policy recommendations are provided to publishers, founders and policy makers. These include predictive strategies for multiplicity and multiculturality monitoring, warning about the interpretation of genetic differences between former groups, calls for participatory local participation and strategies for renewal of incentives, linking authors, data ownership and access links. result

Professor Mills adds: "We take advantage of the different types of data and link them together in a new way to showcase the internal operations of this important area of ​​research. We hope that 10 evidence-based policy recommendations will increase the capacity of revolutionary genomic revolution."

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