Anyone who has been part of a celebrated New Year party knows that alcohol is a little euphoric, energetic and loving. But the more we drink, the more we are born (sometimes, at risk of life) the stupid ones. Scientists behind a new research argue that they trigger emotions from the outset, thanks to some fruit flies.
This research, published this month in the Journal of Molecular Biology, is part of the Nobel Prize-winning scientist at the Scripps Research Institute, a nonprofit research center, and a graduate school in California and Florida.
Based on earlier research, the group theorized that the alcohol-fat brain effects were similar to those of anesthesia. Thus, they want to study the molecular path activated with the nerve cells when they drink or seduce alcohol, the enzyme phospholipase D2 or PLD2. PLD2 binds ethanol molecules to the fat cells stored in the nerve cells or on the surface. And the fruit flies were used as places of public, as the wings stand out as if it were one that looks at us.
"They acted as a person," said Scott Hansen, general secretary, associate professor of the School of Molecular Medicine, Scripps, in a statement. They lose "Coordination, they literally drink."
Hansen and his team put the flies in a small tube and fed liquified with alcohol, and the flies were confronted. When they looked at the brains of these birds, the activation of PLD2 was found through alcohol through the chain reaction of other nerve cell processes. Specifically, PLD2 decomposes alcohol into other molecules or metabolites, and one of these metabolites is a molecule of fat and alcohol called phosphatidylsolol (PEtOH). PEtOH's congestion at the same time stops the nerve cells when they make it easier for their brains to become hyperactive.
"You see more hyperactivity around the fly, which is somewhat more similar," explained Hansen.
Hansen and his team also created the genes that left the brain cells to deactivate PLD2. These flies, unlike incessant flies, did not make much rumors, to help the PLD2 think about the feeling of whirlwind.
The discovery is particularly interesting, the authors say that, because of alcohol, they directly affect the brain cells. But it would be an example of a drug that affects cells individually, via PLD2. It is important to know that being able to stop the worst effects of alcohol. So, nowadays, the drugs that can be safely interacted with PLD2 can be the first to allow us to drink, which can help people with alcohol addiction. Maybe PLD2 could stop drinking to avoid other negative aspects such as brutal hangover.
"He has created different ways of thinking about alcohol poisoning in a molecular level," said Hansen. "Most scientists thought that alcohol had a direct impact. The bulls blockage shows in the running of the bulls is not true."
Fruit flies are substitutes for people, but, of course, brains are not like ours. So much more work is needed to find out whether PLD2 is a human being to get buzzed man. Hansen and his team also have significant PLD2 properties to create important alcohol effects, such as sedation.[Journal of Molecular Biology via Scripps]