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The recently discovered Alzheimer's genes will wait for future treatments



These genes, along with others previously identified, work with tandem to control the functions of the body that affect the development of diseases.

"This is a breakthrough in improving analysis and improving understanding of Alzheimer's disease," said Richard Isaacson, a neurologist at the Weill Cornell Medicine, who is leading the Alzheimer's Prevention Clinic.

"The discovery of these new genes allows vaccines to be targeted by therapeutic interventions for diabetics," said Isaacson, who did not participate in the research. "It also gives us a broader perspective on Alzheimer's potential reasons."

The discovery of the research will not change "everyday life or medical practice" at any time, "said Heather Snyder, Director of the Alzheimer's Association, General Director of Medical and Scientific Research.

"That said," they give us valuable knowledge based on Alzheimer's disease and other dementia, "Snyder added.

Unprecedented numbers

The Hussman Institute of Human Genomics University, a researcher from the international research team, has analyzed the data collected in four centers, two in the United States and two Europe, the data that make up the Alzheimer's International Genome Project.
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The research published in Nature Genetics on Thursday was a genome of the second group's research against a group of people led by a group of people with Alzheimer's disease. The first study published in 2013 includes about 75,000 people and has identified 11 gene loci or locations previously unknown to Alzheimer's development.

When the number rose to 94,000, the new study gave more data to 30% of the study, which allowed researchers to check for up to 20 previously discovered genes and add four.

As a gene called ADAM10 called genes (IQCK, ACE, ADAMTS1 and WWOX), Alzheimer's development occurs. But after understanding and analyzing their specific functions, researchers can say they can develop drug targets.

"Alzheimer's is a complex illness, like Huntington or Parkinson's, a gene changes and you get the disease," said Dr. Margaret Perica-Vance, the Hussman Institute's director.

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"Together with Alzheimer's disease, many genes work together," said Pericak-Vances. "We tried to get rare variants of the genes that could help Alzheimer's, and we could not do that. to make this sample size ".

The study found that Alzheimer's disease was found in genes of amaloids and immune systems, said Professor of Neurology Rudy Tanzi, Harvard, Director of the Alzheimer's Genome Project and member of the international consortium.

"We saw early in the morning, but it was not verified [genome-wide association study], "Tanzi said." So it seems exciting to become an amyloid as an important player.

"I must also say that the other main pathways to other amyloid genes we are seeing are innate immunities," said Tanz. "In this study we are further intensifying genetic immunity genes that cause suspicion of neuroinflammation."

Neuroinflammatory susceptibility is essential, as Tanzi says: "at the end of the day, plates and tangles can set the stage, but the neuroinflammation that kills unwanted neurons is to achieve dementia."

Now, they have a dozen target genes that connect Alzheimer's immunity, Tanzania said it would "facilitate the discovery of new drugs."

Accuracy medicine

The increase in the size of the sample has allowed researchers to find genes of genes that can cause Alzheimer's development. "And some of these genes allow more than one function," said head writer Brian Kunkle, associate scientist at the Hussman Institute.

"Risks can be higher through illnesses," said Kunkle. "The risk and treatment of each person will be predicted for what kind of person there are in these 25 genes or other biomarkers."

Isaacson said he would bring ongoing work "into the most exquisite medicine".

"A person can take several roads of Alzheimer's," said Isaacson. "To find out about how a person works through the identification of the gene, specific interventions that may be preferable for that specific person".

As for what happens, Kunkler is optimistic.

"It's hard to say if someone is helping with Alzheimer's," he said. "Fortunately, there will be treatments developed for those families with a risk of risk."


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