Saturday , January 29 2022

A key nutrient can help fight Alzheimer's for generations


Posted 09/01/2019 8:08:33CET


In the new study, researchers at the Arizona State University Biodesitics Institute (ASU) explore a safe and simple treatment for one of the most destructive and unfavorable imbalances: Alzheimer's Disease (EA).

Ramón Velázquez and Salvatore Oddo, along with members of the Association of Neurodegenerative Diseases Research Association (NDRC) of the ASU-Banner, have studied the effects of cholesterol in the fight against loss-of-loss disorders that may be important in foods.

The mice produced by the test tell the symptoms of AD to show similar symptoms. Results have shown that rodents suffer from diets that suffer from a high number of cholesterol, their children show spatial memory improvements, compared to those who receive a regular queen in the stomach.

Surprisingly, the beneficial complementary cholesterol generations appear to be generational, not only protecting the baby's supplemental cholera supplements, as well as the baby's descendants.

In the second generation, however, they did not receive complementary cholera, however, they did get the benefits of treatment, probably when we had inherited changes. The study of these epigenetic changes suggests ways to promote new research and promote the spread of genetic transgenic genes, including fetal and obesity of alcohol syndrome.


Cholin protects Alzheimer's disease in the brain in at least two ways, which are studied in the new study. First, choline reduces the levels of homocysteine, which can act as a powerful amino acid neurotoxin, with the help of distinctive AD: neurodegeneration and amyloid plaques.

It is known that homocysteins double the risk of Alzheimer's disease development and is at high levels of Alzheimer's disease. Choline makes chemical transformation, homocysteine ​​becomes harmful to useful chemical methionine.

In the second, along with the coline, it reduces the activation of the microglia, responsible for the elimination of brain waste. Although cleanliness functions are indispensable, the activated microgla can be achieved without control, usually in the form of AD. Micro-activation causes over inflammation of the brain and eventually causes neuronal death. Completing cholesterol reduces the activation of microglizies by providing greater protection against AD disasters. The discovery appears in the current issue of "Nature Molecular Psychiatry".


Alzheimer's disease is currently believed to begin the destruction of brain decades before the onset of clinical symptoms. Once diagnosed, the pathology is always deadly and closes a system from another system. Mental impairment is not constant, patients have symptoms, disorientation, delirium, lack of memory, attacks, agitation, and progressive loss of motor control.

Choline is a nutrient that is naturally a bit like a naturally occurring nutrient and is also available as a supplemental diet. It is a metabolic source that is necessary for many steps in metabolism. Plants and animal cells require the kills to maintain their solar integrity.

Corporals use cholesterol to produce acetylcholine, including a key neurotransmitter, memory, muscle control and humor for the brain and nerve function. Choline is also a key role in the regulation of gene expression.

In the study, when the mice received an additional kernel containing the diet, the children had significant improvements in the spatial memory, which were tested in a maze of water. Study of the mouse tissues extracted from the hypokampus, when the brain region plays a functional memory formation, confirmed the epigenetic changes caused by cholesterol supplementation. With microglial activation and brain-linked gene, the reduced homocysteine ​​level has led to improved performance in spatial memory tasks.

Thanks to Chulin's epigenetic changes, the enhancements were transferred to the kidneys of mice who received an additional kerchief in the uterus. The importance of the study is double: the beneficial effect of complementary foods is generalized in generations and proposes epigenetic mechanisms to explain the reduction of the memory deficit against DNA.

Choline is an attractive candidate for treating Alzheimer's disease, which is a very safe alternative compared to several pharmaceutical products. The authors have warned that the daily dose of cholesterol is recommended to produce at least nine times adverse side effects.

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