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Bacterial immune cell deficit increases Alzheimer's risk. A study shows



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Bacterial immune cell deficit increases Alzheimer's risk. A study shows

January 8, 2019 GETTY IMAGES / ISTOCKPHOTO / RAFIK – ARCHIVE

MADRID, JANUARY 8 (EUROPA PRESS) –

The gene "TREM2" mutation may increase Alzheimer's disease by immunizing the brain cells to eliminate toxic deposits, especially in the early stages of the disease, according to a study by the German Neuro-Disease Disease Center. (DZNE) and the Ludwig-Maximilians University in Munich.

The main characteristic of Alzheimer's disease is the formation of toxic deposits in the brain, called plaques. Specialized immune cells called Microglia protect the brain from toxic waste. & # 39; TREM2 & # 39; It is a key factor in activating the microglia and is therefore an important goal for therapeutic approaches. To explore these therapeutic options, scientists have made an exhaustive study of the development of mice with the "TREM2" functional gene and without them.

The mice with "TREM2", healthy, collect microorganisms on small plates that are emerging at the beginning of the disease and allow them to increase or spread. "Especially microglia attracted amyloid plaques, surrounded by individual plates and parts," explains Christian Haass, an article in the Nature Neuroscience magazine.

On the other hand, with the apple that is "TREM2", the microglia can not play an important role. The therapeutic activation of the "TREM2" initial phase helps to prevent the toxic aggregates of beta amyloid proteins.

However, the results of the study should also be careful when doing this type of therapy. TREM2 prevents the formation of plaque at the beginning of the disease, which may have an adverse effect later. In advanced phases of disease, plaques were faster for mice & # 39; TREM2 & # 39; Functional, than the mice that are not in the corresponding gene. The researchers found that "TREM2" microorganisms produce a substance called "ApoE", which improves the formation of aggregate.

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