Shauna Davison, a British teenager, received an experimental transplant in 2012 to extend her life. But after two weeks he died.
Her mother said two patients had reported a similar procedure before the procedure, but never mentioned that other people had died.
The transplant was the same with stem cells and Karen Davison, Shauna's mother, thinks the victim of this experimental technology.
Shauna He was born with a lung, an open palate and a serious heart.
But when he spent his life and outside the hospital, he was a wonderful baby.
"His illness never had a depression, he always had a smile on his face," says his mother.
At the age of twelve, the doctors saw that the trap had trouble. It was very tight and when it was clogged, I could not breathe.
It took 48 hours.
In Leeds, England, the surgeons were saved.
Dr David Crabbe warned that the operation could not work, though Shauna's backbone was rebuilt with his ribs.
The little girl had to be hospitalized for six months. A ring of circulation was kept open to keep it open.
Over the years, when Shauna's body grew, the doctors needed to expand the rings to be bigger.
For that Need to undergo a tracheotomy, breathing in front of the neck.
"We did not think about it at the time to survive," recalls Davison.
He wanted to know how to change the daughter of the trakeotomy tube, how to use physiotherapy exercises that helped improve breathing, accelerating maneuvers and antibiotic antivirals.
"I've done everything," he says. "And Shauna was beautifully dressed, but she did not even know about another lifestyle."
Over the years He had to undergo several operations, but he always moved forward. I had long periods, I did not have to walk in the hospital.
But Dr. Shauna did not find any remedies to remedy Crabbe.
Their air was small and they had to look for other options.
At the age of 15 He suffered a respiratory arrest.
Professor Martin Elliott, cardiovascular surgeon at the Great Ormond Street Hospital in London, and former medical director at the Great Ormond Street Hospital in London spoke about pioneering surgery.
"There have been some studies carried out on tracheal transplants, and both cases of success have been successful, but they could not be discussed with the patient's confidentiality," recalls Davison.
One of them was a 10-year-old boy, he says.
"It was Shauna's only chance," Mum speaks.
An innovative alternative
The transplant was not the most unusual.
He had to be the first They get the donor's trap and then align it with the tissue of its own stem cells, in theory that your body is considered to be a proper organ.
I would not recommend it in any way to avoid medication, always afraid of transplants.
The method was completely innovative with new and still experimental cellular technologies.
In the United Kingdom, the law establishes that Doctors may resort to experimental treatments if the patient has a terminal illness and is not an alternative treatment. It is called "mercy-use".
The physician doctor told his mother that the young woman did not need tracheotomy or ventilation, and would have a normal life.
They also reported possible risks: the normal risks of transplants and anesthetics could be waived.
Make a difficult decision
Shauna continued his treatment at the Great Ormond Street hospital hospital and specialists themselves.
When he asked for future expectations, the young woman said that she wanted to swim one day.
It was an easy decision not to send it to an operation, says Dr. Martin Wallis.
"It was not enough and the decision was not easy," he reflects.
"He had a reasonable quality of life, a good friend, a sense of humor and how he had fun, and that was all the more difficult."
"I wanted to be an operation, I did not want him to feel bad and not be able to do it," Davison justifies.
The team of medicine talked about the success of the success of operations talked about ongoing celebrations.
"They could not determine when my daughter died, but it would not be in the near future giving up his air. Then they told me that he was prepared about this procedure, "says mother.
"Like any other father, if you think you can live with your child, I accept it".
In February 2012, he received a Shauna trap from her cellular mother-in-law lenders.
At first everything went well.
"It was great during two days," recalls his mother. "I could not believe how he recovered after the operation."
But two weeks later an ambulance of the same London hospital had to transport in Leeds, north of the country.
Throughout the journey, many girls began to get bored and need to be constantly stuck in the throat by suction.
"It was strange, but we thought it was a trip," says mother. "I thought: we'll stay for a couple of weeks and we'll be home."
But the next morning Shauna's health increased.
"She was crushing her breast," says Davison, who still remembers what her daughter says: "Help me help."
"It was the worst day of my life, it could not help."
Shauna's new trap stopped.
"He tried to breathe hard, saying that his heart stopped, he was a wonderful girl, I lost so much."
In 2008, he made the first transplant with the donation of a trap that covers the patient's cell mothers, which he made in the press in the world.
That was what he thought Remove the cell surface from the tracer surface and the fermented stem cells It was like creating a new organ of the tissue of the patient.
Medications were not necessary to prevent rejection of the body of the organ.
Paolo Macchiarini, a surgeon from Bristol University, underwent surgery with Martin Birchall.
The recipient Claudia Castillo, a 30-year-old woman, had a tuberculosis affecting her bronchus.
His case appeared in the prestigious scientific Lancet. After five months of intervention, he was healthy.
"It was seen as revolutionary and innovative … and a new and hopeful technology was created that combined mothers and artificial cells, creating a new hope for regenerative medicine," recalls John Ras Professor, President of the International Cellular Association.
He had "smell" PNobel Prize "He says
In fact, the Nobel Prize in Medicine, the prestigious Stockholm Karolinsk Institute, offered a position in Macchiarine.
Birchall, on the other hand, at University College London (UCL), Macchiarini was also an honorary professor.
It was not other success stories They also occupied the press room, but soon there were some questions about transplant trains set up with creditor cells.
Macchiarini abandoned the use of a plastic trace (donated donations) and spying on cell mothers.
The results were unpleasant: the patients were killed.
Macchiarini Karolinska Institute investigated several times before shooting. Claims against him were previously excluded, but later, the organization was named guilty of scientific misconduct and many articles have been removed from the scientific journal.
The Swedish prosecutor's office opened again criminal negligence investigation against him in December last year. The accusation has always been denied.
Begin to make justice and make contact with one of the a huge number of top dentists in University Center we've on this web site to find a expert who'll struggle for the lead to and finish your fight. Say your privileges. Chinese Our directory offers a useful tool that will help you discover a chinese restaurants in Birchall most suitable to your situation. therapeutic role "in the operation of its patients, Ciaran Finn-Lynch, this boy of 10 years was successful and Shauna's mother was mentioned.
Martin Birchall was the main person in charge of directing this essay. He and his team would give millions of pounds to the university in research funds.
UCL has made a new report on regenerative medicine. In 2017, he published the results of a special study after Macchiarine's revelations, where there was no mistake in Birchall's therapies. He opened the doors for clinical trials.
But Shauna Davison's family I did not know how to create doubts Only one alternative to save her daughter was presented in relation to innovative treatment.
Together with Ciaran Finn-Lynch and Claudia Castillo, they talked about two well-known cases.
But they did not say Castillo's traction transplant was complex after having received more than three weeks and needed a strain to keep it open. Then she had to get rid of a lung.
They did not know that Martin Birchall spoke in most other cases in 2010.
One of them is Keziah Shorten, a teenager. Two years ago, Macchiarini, a hundred Texas Florentine engineer, was diagnosed after being diagnosed with a rare type of cancer.
His transplant operated one year.
Martin Birchalle told the Swedish documentary about 2016 that the trap was broken. After being operated at the University College London hospital, it was replaced by plastic. He died a month before Shauna's operation.
According to John Rascus, there is no "The obligation to provide full and honest information about the available information. The exclusion of serious cases is totally unacceptable. "
A spokeswoman for the Great Ormond Street hospital told the BBC: "As a patient, Keziah's condition and grafting were very different from Shauna, so it was not clinically important to discuss his case."
Other patients in the hospital did not mention that "the group did not find other important cases abroad abroad".
But he did not know Karen and Shauna.
But Ciaran heard about Finn-Lynch There were great differences Between its operation and Shauna.
Ciaran picked up a trap ring. Shauna, no.
According to the UCL research report of 2017, Dr. Martin Elliott has said he wanted to use it, but it should not be used.
Ciaran also received the trick from a new donor. Shauna froze and then thaw.
Was Treatment previously unused.
Trish Murray, an American cellular biology and regenerative medicine professor at the University of Liverpool, England, is very critical in Shauna's case.
"That is true If you do not have a ring ringCan collapse This has been all the experiences, without exception, for tracheal transplant patients, "he says.
"Therefore, we know that they cause problems, if one of these rings is not used, the trap will collapse and the patient will be drowned."
It was another problem frozen trachea.
He made a great sense to donate the donor to freeze the organ so that it was saved and deconfigured.
Trish Murray also criticizes the decision.
"Ciaran's trace was not frozen before, about Shauna's and we know about the documents in charge of this case. They know that the windpump weakens… after the transplant, the collapse, "he says.
UCL questioned the importance of these studies and told the BBC that these reports do not refer to the techniques used in the age of the deceased.
Murray says a lot Other studies should turn on an alarm. Moreover, it questions the role of stem cells.
"Indeed, there is no evidence that any of these cells survive, that there is not enough evidence," Murray defends.
But how do you find out about how to deal with doctors and scientists who are seriously ill to patients?
In general, researchers must test innovative treatment in the laboratory and then in preclinical animal studies. Then, with the formal approval of the research ethics committee and regulators, human experiments have begun.
but It is in a legal vacuum that covers these cases. They are called compassionate studies.
He wrote Martin Birchall Lancet "the procedure for the use of new treatments in patients with illness" is "compassionate studies" and is "accelerating the attempted bilingual therapy".
"Surgeons use the prone to use this apparent loophole to experiment with patients, and then use the data obtained to reach regulatory authorities and thus to obtain authorization to continue the trial," says Trish Murray.
John Rasko agrees with Trish Murray This is not how the system should work.
"Pity use is a great responsibility and the doctors do not have to use strictly non-compliant medical treatments," says Ras.
And the Great Ormond Street hospital also agrees. "We do not use mercy as a way to test new treatments," the spokesman said.
But Shauna's transplant and other patients were used to obtain funding and follow-up of clinical trials.
They also wrote at the Medical Magazines and the European Medicine Agency.
The BBC found this At least eight of these documents and publications are at least Shauna's treatment or death are incorrect.
For example, Martin Birchall's European Medicines Agency referred to the 2016 request that Shauna's early surgery was successful, but "six months later" suffered a serious cardiovascular complication. In fact, after two weeks he died, because his job was stopped.
Adopted and financed by public entities to establish clinical trials for the treatment of transplants, a change was made in the procedure.
Upon learning about what happened to Shauna, The team demonstrated that patients involved in the trial should use a trap ring.
However, although this was done, the information on patients with these tests had misinformations about Shauna and Claudia Castillo.
Ciaran Finn-Lynch only included his cases in the information tab, although the team had 10 cellular tracers around the world to find out about cell transplants.
It was not until 2014 that Martin Elliott said in a speech that 10 patients had been trapped with tissue engineering and all Claudia and Ciaran died.
Last year, Clinical trials were interrupted du UCL No one has ever hired anybody to participate in such experiments.
A large part of what the BBC fancied about Shaun did not appear in the UCL's special research report.
Leonid Schneider is a molecular biology of cells, a journalist that covers regenerative medicine since 2016.
He declared UCL in the field of research and questioned certain cases.
"Why did not Shauna's mother have complete information? Which idea was not a ring?" He asks.
"And, how could the UCL researchers recommend the trap of the donor to recover clinical trials, after the teacher Delaere and I told how many people died of this disease?" He adds.
UCL defends itself: "It needs all the research done at UCL they meet the highest standards legal, ethical and regulatory; and we will not question the necessary measures, if this is not met. "
After receiving an ethical advice, the BBC informed Karen about the tissue engineering transplants.
He was angry He said this information It could change the decision to influence Shauna.
"I hope that anyone who does not pass through is what I expect. They must stop. This is shock. People asked me: "How does Shauna die?", And I always say, my heart. I never die of innocent people. They have a lot of answers".
In the Surgical Surgery Hospital, in this case he commented: "Before doing Shauna's surgery, all the science and medical sessions published were thoroughly studied".
They added: "Shauna did not work by Shauna, and her family thought they did not receive all the important information. We want to meet with them to be able to talk about things like that."
"It has taken everything all the time, I would think the phone came and they said something long ago," complained Karen Davison.
"I know I would not have been forever, but at least I could have a bit more."