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Chinese researchers identify a new gene that increases Alzheimer's risk



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Updated 12/29/2018 – 09:02

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BEIJING, December 28, 2004 (Xinhua) – A Chinese research team has identified a variant of a gene that plays a key role in the development of Alzheimer's disease in large Chinese ethnic groups.

Research has been published in the National Scientific Science, English magazine of the Chinese Academy of Sciences (ACCh).

Alzheimer's disease is a progressive and irreversible alteration in the brain, memory, cognitive abilities and at the same time the ability to perform simple tasks. The disease affects around 48 million people around the world, as expected by the aging population. The disease has no cure.

Disease appearance and progress are conditioned by genetic factors and environmental factors and are inherited by a percentage of cases.

Previous studies found the genes that appeared at the beginning of the Alzheimer's family, diagnosed for 65 years and only 5% of cases. Scientists believe that other genes that have not yet been discovered.

The latest genome research studies have identified a number of Alzheimer's genes in European populations, but most of them can not be validated in Chinese populations.

In addition to the 107 genetic sequencing or family history of 107 Alzheimer patients diagnosed with 55-year-old diagnosis, the researchers at the Kunming Institute of Zoology, ACCh, found a strange variant found in rs3792646, C7. Then there were 368 cases in South-East and South-West China.

Additionally, experts believe that patients with this risk variant had a significantly lower part of the right volume of the hippocampus as a major part of the brain, which was an important part of the brain; . This finding indicates that the variation of the brain's structure and decades can function before it reveals the disease.

The following studies showed that the excessive expression of the variant could prevent cell viability, immune activation and neuronic activity.

Variable is likely to be Chinese, after analyzing data on the genetic sequencing of 812 patients in the world.

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