Madrid, January 29 (EFE) .- A team of researchers has demonstrated that due to the immune "clock" that controls infections and cardiovascular disease, the authors claim that it could have "significant health impacts".
The results have been published on the cover of the Immunity magazine and by the scientists of the National University of Cardiovascular Research Center (CNIC) of Spain.
Neutrophins are a type of leukocyte that is the main line of defense of the body, but can damage healthy cells and cardiovascular systems.
In a note, according to the CNIC, it detects the presence of immunologic clocks when cells are activated, when they are excreted by blood circulation at night.
Specifically, a series of molecules have been identified with neutrophils of light and dark diurnal patterns (ie cirrhosis) and the neutrophils that regulate their migration and location within their organism. José María Adrover first explained the work of Andrés Hidalgo CNIC team.
The immune system, especially the neutrophil, allows millions of millions of humans and thousands of microscopic beings (bacteria, fungi and viruses) to effectively eradicate microorganisms that infect our disease; However, this problem creates a problem because the immune response is often unbundled and harmful to healthy tissues.
This, says Hidalgo, "occurs, for example, in myocardial infarction, a coup or lung acute."
The biological dilemma is to control the immune system to protect against infections, but it does not cause collateral guarantees and this work responds to this problem.
In order to reach their conclusions, researchers use mice as a genetic technique, together with a high resolution microscopic image, to adapt the behavior of these leukocytes to the different moments of the day.
In addition, infected animal models, traces and infections have shown that the handling of the clock significantly changes the immune response.
"The animals that handle this watch genetically in a certain way become resistant to the whole infection, but very sensitive to heart," says Alejandra Aroca, one of the authors.
Researchers found that during the day neutrophils cause more damage in the case of infarcts, but they are more effective by eliminating pathogens that attack the tissues.
In fact, a similarity to human clock immunity is not absurd, according to scientists, most of the deaths in developed countries are due to cardiovascular damage.
Additionally, most of these clinical events occur early in the morning; That is to say, the circus model continues.
"If we can control this watch, we can take advantage of this patient-friendly phenomenon," Aroca concluded.
In this sense, they are looking for ways to manipulate this clock to promote a day or night immune system through drugs, depending on the patient's interest.