Scientists believe that one of the two driving forces with chronic pain is the only health problem in prevention and burden, remembering previous pain. Research published on Thursday in the Current Biology suggests that, according to sex, it may create variations, that pain mice and humans are remembered.
A research team led by Canadian colleagues at McGill and Toronto Mississauga, men (and male mice) remembered previous painful experiences. As a result, they emphasized and returned to the place where they had previous experience when they suffered the pain.
Women (and women) were not reminded by previous experiences of pain. Successful translators, mice and males think the results of the researchers will potentially help scientists to look for future treatments for chronic treatment.
The discovery was totally shocked. "We performed an experiment to see the hypersensitivity of mice pain and found surprisingly different levels of mice and female stress," explained Jeffrey Mogil, Professor of Pain Studies, McGill's Psychology and Alan Edwards Center Pain Research.
And it continues: "So, human beings have decided to extend the experiment to see that the results could be similar." We were amazed that the same difference between men and women we saw in the mouse.
"It was amazing that men reacted more, because women are more men than men who are less sensitive and are generally more stressed," said Loren Martin, first assistant professor and assistant professor at Psychology at the University of Mississauga.
In experiments with humans and mice, subjects (41 men and 38 women aged 18-40 years) were brought to a specific room (or placed in a test container in a specific way, species), due to the heat generated by the heat of the inflammation or the forearm, They had low levels.
Humans calculated the mechanical point at 100 points on the scale and the mice "rated" the pain as they were moving away from the heat sources. After the initial pain experience, patients experienced livelihoods in Pavlovian atmospheric stimuli.
Human subjects had an inflammatory pressure on hypertension and used spiders for 20 minutes. This is unbearable and only seven out of 80 subjects get less than 50 points at a 100 point scale. Each mouse received a diluted vinegar injection that could cause stomach cancer for about 30 minutes.
BLOCKING MEMORIES MAKES PAIN WITH DISAPPEARANCE
To observe the role of memory in the experience of pain, the next day the issues returned to the room or to another room, in a room or in a room for other sessions. Once again the heat was applied to the arms or leg legs.
When (and only when) they were taken in the same room as the previous test, men were much worse than men and women who had a higher prevalence than the previous day. Also, male mice, but not female ones, responded to the same environment as they responded to heat mutation, because rodents were placed in a new and neutral environment.
"We think mice and men have advanced their sleeves or vinegar and, for men, the stress of this progress caused more pain," says Mogil. "The reason was to have the pain more sensitive. The second day, but there was no reason to expect men to be specific, that was absolutely astonishing."
In order to confirm that pain pain has increased due to previous memories, researchers injected mice mouse males in memory, using medication called "blocked" in memory. When scientists recalled the pain experiment, mice did not reminiscence of signs of pain.
"This is an important finding that more evidence is that chronic pain is a problem that we recommend that you remember, and this is the first time that translates pain in translation, rodents and humans," says Martín, Canadian Level II Research Professor, Translazio Mina In research
He added: "If you remember, pain is a chronic pain agent and when we remember pain, we can help some patients to treat mechanisms directly behind remembrances." "This research acknowledges the memory of pain that can cause pain," concluded Mogil.