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The body clock relates to mental health and illnesses

Publication date 01/30/2019 7:33:31CET


A large-scale genomic analysis reveals some mechanisms of the body clock to determine how mental health and illness relate. Studies published in "Nature Communications" suggest that higher wellbeing and risk of schizophrenia and depression may be genetically lowered; But the results did not show strong links to diabetes or obesity-related diseases.

The study was conducted through international cooperation, Exeter University, United Kingdom, and the Massachusetts General Hospital, in the United States, and funded by the Medical Research Council. It highlights the essential role of the retina to keep your eyes on the body. It also increases the well-known genome fields to find out whether 24 to 351 birds are premature.

Professor Mike Weedon, at the Faculty of Medicine at the University of Exeter, said: "This study highlights some of the genes that can be looked at for more details, so that people can have different body clocks. In our research, many people mean" night owls " It is more likely to have greater mental health problems, such as schizophrenia and lower health wellbeing, but more studies are needed to fully understand this link. "

US-based research 250,000 people attended 23andMe, private genomic analysis and 450,000 people in the UK Biobank study. All participants were asked whether they were "early morning" or "night-time", and their genomes examined the genes that had their routine effect on their genes.

The researchers confirmed their results using more than 85,000 people in the British Biobank using bracelet activity tracking information. This information genetic variant identified by scientists could change a person's 25 minute natural length, for example, when people spend hours, from 8:00 a.m. to 8:25 a.m. Scientists have genetic areas to sleep, but not sleep quality or duration.

The identified genomic regions are: our body clocks, also known as circus rhythms, and the genes in the brain and the retina. The body clock cycle is slightly longer than the 24-hour cycle. The connection of the tissue of the gums to how to recover the brain's light can be explained by how to describe the body clock for each day with the 24-hour cycle.

Our body clocks cause genes and lifestyle factors, such as diet, artificial light and our work and activities. Our body clock includes many molecular processes, including hormonal levels and body temperature, as well as our tranquility and sleep patterns.

Dr. Samuel E. Jones, CEO of Exeter University of Medicine at the University of the United Kingdom, says: "The key mechanism of the brain's body clock recently discovered the Nobel Prize in Physiology in 2017. However, we still know that your body's clock is still causing your illness. Whether or not he is. "


"Our work shows why some people are in line with the fluid and others are night-time owls, because our brains respond to external light signals and the functioning of our operation. Internal watches. Small differences can have negative effects on the rhythm of our body clock probabilities in an effective way to keep up the risk of both disorders and mental health disorders, "he added.

Dr. Jacqueline M. Lane, secretary of the Anesthesia Department at the Massachusetts Hospital Hospital, adds: "To understand genetic soil and general time of work, we also get information on possible therapies with the general population, like those with extreme conditions, acceleration disorders or delayed rhythm acceleration" .

Dr. Rachael Panizzo, Director of the Mental Health and Addiction Program of the Medical Research Council, says: "We know how body clock works and how our health and well-being are connected, but until now we know little about the genetic part."

He said: "Now, with the help of public data sets in the UK, researchers can study unprecedented scale, interaction between body clock genetics and mental health risks, schizophrenia and depression, this study offers a valuable new vision, we expect to be at greater risk more effective intervention ".

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