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The parent's biological clock is faster than expected – 12/02/2018



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The biological clock also makes dads. And recent research suggests that it is faster than thought.

It was considered until nowHe was 55 years old A study by Stanford University School of Medicine that reviewed more than 40 million births due to the increase in chromosomal changes in sperm due to the age of father's childhood health. The risks are 35 and over 45 are over.

Among those over the age of 45, 14% have been detected early infants

Specifically, Stanford scientists say that There is a risk to a child who is experiencing problems with age at a later ageLow-level convulsions, respiratory need help, or a neonatal intensive care unit (IUCN).

The study data, published in the British Medical Journal, suggest that after having controlled the variables such as the age of the mother, race, education, education, civil status or smoking history, For over 35 years, the dangers of birth have increased For more than one males each year, it accumulates two new mutations in the sperm DNA.

In the case of parents over the age of 35, the risk of birth has increased; In fact, more than one males per year accumulate two new mutations in the sperm DNA.

In the case of parents over the age of 35, the risk of birth has increased; In fact, more than one males per year accumulate two new mutations in the sperm DNA.

therefore, Children born to 45 years of age or older are born more than 14% before being born, low weight and approved in the IUCN. Parents with between 25 and 34 years of age (the average age of paternity in the United States). and The seizures increase the risk, According to the report's data, 18.% After 50 years of age, the need for ventilation from birth to 10% was greater and the need for ICU increased by 28%.

Specifically, according to Stanford scientists, older parents are likely to have a higher risk of pregnancy: low-weight convulsions, needless respiratory care or intensive care for infants (UCIN).

Rafael Oliva, the epigenetic and epigenomic specialty of spermatozoa and the reproduction of idibaps, the UB professor and the molecular biology biology team of the biomedical research center clinical diagnosis, are not surprised. "The job is interesting and what the other studies are about to show: we thought it was more important than father's role in the health of pregnancy and son and the male biological clock, "he says.

As older parents, babies will have a higher risk of birth problems, says a new study.

As older parents, babies will have a higher risk of birth problems, says a new study.

Julio Herrero, head of the Vall d'Hebron Support Assistance, believes that this research is important It carefully examines a factor: the age of male parents is usually not taken into account He was 55 years old. However, the specific results of the study should be carefully considered, because it is a retrospective study, according to the doctors or parents that were in the 40 million birth ranges, whose mothers are very broad in age, even if they are not at risk of their father's age whether from the age of the couple or from the first children of that woman. "It's important to study the age of paternity and the incidence of male biological clocks Deeper, but in the future, parents must take their mother as a control group, "says Herrero.

Alvaro Vives, Head of the Dexeus Male Unit, agrees that it is difficult to study in many cases because in these cases there has been no bias, although men can change their age chromosome levels and cause problems with the fetus. "In fact, in Catalan public health, access to in vitro fertilization is limited when women are over 38 years old or at the age of 55," he explained. Vives believes that many gynecologists who perform fertility centers pay more attention than womenr, "but 50% of fertility is a human responsibility and there are many factors and habits – toxins, coffee, tea, excess weight, tobacco … -" the quality and fertility of spermatozoa, changes in pregnancy development and early babies or respiratory problems they may create, that is, according to Stanford.

"An interesting job and other studies show that father is more important than thinking about pregnancy and childhood and also a male biological clock"

Rafael Oliva, specialist in epigenomic epigenetics and spermatozoa

The European Society for Reproduction and Embryology presented a study by biologists from Harvard University in 2017 after studying 19,000 in vitro fertilization treatment. When young women were treated with men over 40 years of age, pregnancy failed. On the other hand, the best result was when the man did not reach thirty years of age.

As older parents, babies will have a higher risk of birth problems, says a new study.

As older parents, babies will have a higher risk of birth problems, says a new study.

From the epigenetic field, Oliva explains that everything transmitted by the sperm is very little in human beings, but in the last two years, male life shows that animals accumulate. they can also eat experiences that live, They measure your changes in sperm and move on to the next generation and sometimes even to the third. "We are addressing concern about motherhood. Ozitons are very common in sperm, and for a long time, babies were thought to be inherited only by DNA through cytoplasmic oocyte factors, because spermatozoa only had DNA, but today it is very clear in sperm history and protamins have the father's genome to organize histories and protaminas and have the ability to provide epigenetic information, "explains the idibaps researcher.

This week, the PNAS scientific journals a group of doctors in the US have hindered the structure of the mitochondrial DNA-cell-energizing belief that they are transmitted only from motherhood. three dozen parents from two different families who inherited mitochondria. Researchers, however, believe that there is a chemical label that destroys their father's mitochondria when cytokin enters into a general rule. However, The finding is that a person who receives a biological inheritance overcomes the sequence of genes and marks the two parents with a mark that has left their way of life, habits and the environment.

Source: La Vanguardia

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