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They create proteins that can help create antibodies to combat HIV

Posted 02/27/2019 4:53:18 PMCET


Researchers from the Penn State School of Medicine (United States) have created proteins that mimic different characteristics of the surface of HIV and that could help create antibodies to fight the virus.

"We have shown that by using our designed proteins, the blood could spontaneously generate antibodies that can inhibit HIV infection in cellular models," scientists said, whose work has been published in the journal 'Nature Communications'.

The researchers used computational models to design proteins that would imitate the preserved protein surface of different strains of HIV to be used in the vaccine. While normally the proteins are designed by changing an amino acid at the same time, the experts wanted to try a different approach.

After creating immunogens that used the new proteins that imitate HIV, they immunized the rabbits and extracted blood samples once a month. Thus, after analyzing the samples, the researchers found that the blood contained antibodies that could be linked to HIV.

"While the findings are promising, there is still more work to be done. It is important that we could generate an immune response to HIV and show that it is possible as a proof of concept. But we still have to improve the neutralization capabilities of antibodies and others aspects before it can become a viable vaccine, "said the experts.

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