Austrian researchers were able to identify a mechanism of the HI virus that they did not know before, which plays a key role in reproduction in the human body.
Innsbruck (Austria). Even though medicine has made tremendous strides in recent years and HIV can be treated better and better, the infectious disease is still not fully cured. Although doctors have managed to cure some people with AIDS, comprehensive treatment of all those affected is not possible today for a number of reasons.
Now Kathrin Breuker and her colleagues at the Institute of Organic Chemistry at the University of Innsbruck have made a completely new discovery: they have discovered a previously unknown mechanism that plays a major role in multiplying the HI virus in the human body. Specifically, this means that researchers have found a new link site that may be of interest for future therapies.
Doctors and scientists around the world are looking for more effective therapies to treat AIDS. The focus of the research is mainly on the fight against the virus, but also on the mechanisms that prevent multiplication.
In order to settle in the body, the HIV virus enters human cells and builds its genetic information into the DNA nucleus. In this way, altered mRNA is generated, which obtains fluid from the cell nucleus and modifies the proteins so that they can be used for virus replication.
Stop the spread of the HIV virus
To get the mRNA virus out of the cell nucleus quickly, it needs eight to ten molecules of a very specific protein. So far, however, it has been completely clear in RNA exactly where and in what order the rev proteins bind. However, if you understand this process in detail and have knowledge of the attachment, you can stop multiplying the virus.
With the help of a completely new method, the researchers closely examined the mechanism of virus replication and found a new binding site. Rev proteins are trapped here and pass to long-known binding sites, which allows the formation of stable RNA-protein complexes.
That’s where future therapies can proliferate and stop the HIV virus in the body. The researchers reported in the journal Nature Communications that the new research findings are not only interesting in terms of new AIDS therapies, they also explain older research findings that have not yet been partially or partially understood.
Nature Communications, doi: 10.1038 / s41467-020-19144-7