Friday , November 27 2020

Research says obesity can worsen breast cancer



Brazil agency November 22, 2020

According to a study by the State University of Rio de Janeiro (Uerj), fat people have blisters that are removed by fat cells, which can increase the inflammatory process in the bloodstream or lead to worsening cancer. breast cancer, if the person has cancer. The research team is linked to the Onkobiology Program, a project that brings together various organizations involved in the teaching, research and dissemination of cancer biology and is funded by the Cancer Foundation. The study was published in the international journal Endocrine-Related Cancer.

Alfredcaff, S epidemiologist and medical advisor at the Cancer Foundation, clarified to Agência Brasili that more research is needed to ensure that obese people are at greater risk of becoming more aggressive and invasive breast cancer cells than those who are not. fat. This initial study is important, on the other hand, because it “opens up a world of possibilities, both for diagnostic testing and therapeutic techniques.” This is the next step in the investigation.

Factors

In Alfredo Scaff’s assessment, there is a fairly in-depth study of the genetics and biology of cancer in which researchers are identifying factors that may exacerbate the disease. “People with associated factors may have more serious cancer than people who don’t have those factors,” Scaff said. He added that these potential factors are areas that could be the basis for the production of drugs or forms of therapy that can be taken by the entire population, later creating treatment methodologies that will minimize the condition. to control or even cure cancer. “There is still a lot of research to be done to get more meaningful conclusions about this research,” said the advisor to the Cancer Foundation.

Scaff said obesity is a combination and severity factor in a large number of diseases. “Obesity is considered a more serious factor in many diseases, especially chronic degenerative diseases.” The team led by Professor Christina Barja-Fidalgo has found that extracellular vesicles (Evs), released by fat cells in fat, have a high inflammatory potential. “This inflammatory potential for a person with cancer or a tendency to develop the disease leads to the cancer being more severe than that of a person who is not obese,” the epidemiologist said.

He believes that if a drug is found in the bloodstream that blocks these extracellular vesicles or if that person loses weight by reducing the blood circulation in these vesicles, the cancer may be less severe or less aggressive. Subsequent studies will lead to the development of new evidence or evidence to prove this.

Pandemic

Obesity in the XXI century of man. The World Health Organization (WHO) believes that the pandemic of the century is a global public health problem, linked to rising rates and an increased risk of breast cancer. More than 55% of the Brazilian population is underweight, according to the Brazilian Institute of Geography and Statistics (IBGE). According to the National Cancer Institute, José Alencar Gomes da Silva (Inca), excess fat can cause 16 types of tumors.

The research team led by Professor Christina Barja-Fidalgo intends to investigate the content and characteristics of extracellular vesicles that are now eliminated by fat cells. The goal is to know the main molecules that can be linked to the deterioration of breast tumors and how to contain the action.




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