Researchers are trying to find the genetic roots of Alzheimer’s disease in Portuguese
Portuguese researchers from the Coimbra Hospital and University Center (CHUC) and the Van Andel Institute, from the United States of America (USA), are trying to find the genetic roots of Alzheimer’s disease in the Portuguese population.
“We are conducting a study on genetic risk factors for Alzheimer’s disease in Portugal because we believe it will help us better understand the disease and achieve better and personalized treatment for our patients in the future,” explained Dr. Miguel Tábuas Pereira and Dr. Isabel Santana, neurologist at CHUC Neurology Service.
This year, with two CHUC researchers, Professor Rita Guerreiro and Prof. Dr. José Brás of the Van Andel Institute received a five-year fellowship and a $ 3.7 million (US dollar) grant from the National Institute on Aging (part of the National Institutes of Health) to study the genetic trend in Alzheimer’s disease in the Portuguese population.
The CHUC stressed that it is “the first study of its kind” in Portugal and that “even the largest, a total of 25 families, 2,500 specific cases of Alzheimer’s and 2,500 controls are planned during the project”.
The samples will be collected in collaboration with Dr. Miguel Tábuas Pereira and Professor Dr. Isabel Santana, and then together, “the researchers will identify common and rare variants associated with the genetic risk of Alzheimer’s disease, the genome of a sample of the Portuguese population.”
The CHUC explained that “these data will be combined with genomic data publicly available to non-Portuguese populations to increase the diversity and statistical power of ongoing international research.”