Instead, Hyde-Smith has spent the days leading up to Tuesday's election mired in controversy that evoked the state's dark history of racism and slavery.
On Tuesday, Mississippi voters will decide between Hyde-Smith and Democrat Mike Espy, who, if elected, would be the first black senator's state since Reconstruction.
The result will finalize the balance of power in the US Senate. As it stands, Republicans will hold 52 seats next year, and Democrats will have 47. A win for the GOP in Mississippi would further pad the majority party in the Senate, even as Democrats have taken a strong majority in the House.
The state is polarized along racial lines, with most white voters supporting Republicans and almost all black voters supporting Democrats.
Democrats hope Hyde-Smith's comments will lead to a surge in black turnout and propel them to victory. However, even if black voters, who make up almost 40% of the state's electorate, come out in full force, Espy would still have to outperform the history of his party with whites to have the chance to win.
And Democrats have to overcome partisan trends in the deeply red state. Earlier this month, when multiple candidates in both parties were on the ballot, Hyde-Smith and conservative Chris McDaniel combined for 58% of the vote, while Espy and Democrat Tobey Bartee got 42%.
On the eve of the election, President Donald Trump held two rallies for Hyde-Smith in an attempt to turn out the Republican base.
He told the crowd in Tupelo to "get out" and vote in Tuesday's runoff.
"I think it's going to be a big day for Cindy, but do not take any chances," he said. "That's happened many times before. That never works out well. Just assume you have to vote."
Even though Republicans will control the Senate regardless of the outcome, the President suggested that a Democratic win in Mississippi would "revoke" the victories of the party.
"We can not allow Nancy Pelosi and Chuck Schumer to revoke that victory by winning the state of Mississippi," he said.
At a roundtable in Gulfport, Trump called Hyde-Smith's comments about a public hanging "sad and a little flip."
"When I spoke to her – she called me – she said," I said something that I meant exactly very different, "and I heard an apology loud and clear," Trump said.
"I know where her heart is, and her heart is good. That's not what she was meaning when she said that," he said.
Hyde-Smith at the center of controversy
Though public polling has been limited, the race is seen as potentially competitive because of Hyde-Smith's "public hanging" remarks.
Those comments prompted more depth into its history.
Over the weekend, CNN reported that Hyde-Smith once promoted a measure that praised an armed Confederate's effort to "defend his homeland" and had pushed a revisionist view of the Civil War.
Espy's campaign hammered Hyde-Smith with television ads that cast her as a embarrassment to a state that has tried to overcome her history of slavery and racism.
"We've worked hard to overcome the stereotypes that hurt our economy and cost us jobs. Her words should not reflect Mississippi's values, either," the narrator said in one ad. The ad also called Hyde-Smith "so embarrassing, she'd be a disaster for Mississippi."
Several companies that had donated to Hyde-Smith's campaign, including Walmart, publicly withdrew their support for the senator over the "public hanging" comment.
In her debate with Espy, Hyde-Smith said she would "certainly apologize" to anyone who was offended by her remark. But she quickly pivoted into attack mode.
"I also recognize that this comment was twisted and it was turned into a weapon to be used against me," she said.
GOP fights to avoid embarrassment
While Hyde-Smith largely stayed off the campaign trail, the party's infrastructure rallied to her defense. GOP groups spent $ 4 million on the Mississippi runoff – much more than Democrats' $ 1.2 million, according to Federal Election Commission filings. Republican groups spent more than twice as many Democrats on television advertisements, for the ad tracking firm Kantar / CMAG.
Trump's visits to Mississippi on Monday night were also seen as a bid to rally the Republican base to vote in an election taking place two days after the Thanksgiving weekend.
For Democrats, the best-case scenario is similar to how Democratic Sen. Doug Jones defeated Republican Roy Moore in Alabama a year ago: a narrow victory fueled by massive turnout from black voters.
But Mississippi is, in some ways, more challenging than Alabama. Moore faced allegations that, as an adult, he had sought sexual relationships with teenage girls.
And the state is more rural than its eastern neighbor. Like Alabama, Mississippi has not voted for a Democrat in a presidential election since Jimmy Carter in 1976. Trump won Mississippi by 18 percentage points in 2016.