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Bacteria and the interaction between immune cells that protect the intestinal fence



Lactobacillus genus bacteria may interact with the presence of microbial cells with the cells of the immune system and thus strengthen the intestinal barrier according to the Complutense University of Madrid (UCM) and the National Cardiovascular Research Center. (CNIC), two institutions in Spain.

Research in the study, mice and Immunity opens up a new pathology pathway, such as ulcerative colitis or Crohn's disease, in which case the individual's intestinal fence weakens the bacteria escaping from other organs. inflammatory processes.

So far, there are some examples of some mouse microbial suppositories that stimulate the immune system and only stop the niches of the lymphocytes that promote bacteria.

"Our studies show that they are molecular models or they are secretary of intestinal bacteria," says Salvador Iborra, researcher at the Department of Immunology, Ophthalmology and ORL Department of the UCM. .

The interaction between beneficial bacteria of the Minctro and Lactobacillus genera occurs in the intestinal regions called Plateres de Peyer and promotes a beneficial host response.

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Peyer's plate. (Photo: Salvador Iborra)

In order to carry out this research, experts used mice receptors in the Minta receptor, or those proteins related to intracellular signal receptors called Syk.

The researchers found that, due to this lack, the guidelines needed to create essential lymphocytes to regulate immune function in the vascular tubes were not produced.

"As a result of the decline in lymphocyte populations, we notice the deterioration of the intestinal function function, which increases the growth of bacteria capable of escaping the intestine, and it reaches the liver, causing inflammation and metabolic changes." Explained.

From the results of the study, a new strategy opens "the use of probiotic beneficial microorganisms", which is capable of interacting with recipients or prebiotics that are able to promote the growth of these intestinal bacteria, "says the researcher. UCM also offers another option: Treatment of synthetic compounds linked to Mincer and to promote a beneficial brokerage.

Inflammatory inflammatory diseases, stress, poor diet or medication abuses are factors that can undermine the intestinal barrier.

Together with UCM and CNIC, it includes institutions from other countries, such as the University of Oxford, the University of Manchester, the Saclay University in Paris, the Sorbonne University and the Zurich University, among others. (Source: UCM / DICYT)


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