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Early use of antibiotic patients with reduced sepsis

Early use of antibiotic patients with reduced sepsis
© Imperial College London

Urinary Tract Infection (UTI) is the most common bacterial infection in older patients and the most common Escherichia coli is a uropathogen in the community of over 65 population. The UTI spectrum decreases from severe auto-limiting illnesses with severe sepsis with a 20-40% death rate.

UTI diagnosis may be a serious problem in older patients, patients have a typical clinical history and localized urinary symptoms compared to younger patients. In the new Imperial College London, scientists suggest that urinary tract infections prescribe first-class antibiotics for patients with reduced risk of sepsis and death.

This finding provides more evidence for doctors to make clinical decisions about training for urinary tract infections (UTI) and treat symptoms of treatment treatment when it comes to treatment, in order to use excessive antibiotics.

Scientists at the age of 65 registered a total of 157,264 patients in England, and their GP was diagnosed as suspected or confirmed by UTI.

Patients were immediately recommended for antibiotics (87 percent of the cases studied in the exploration), 7 days (6% of cases) were postponed anti-biotic, or they did not get antimicrobials at any part of the imagination (7%). in the case of cases).

Immediately 0.2% of the patients receiving antibiotics have sequenced in the next 60 days. After the available information on age, sex, existing illness and other personal characteristics, the results were revealed when patients with immediate antibiotics, antibiotics or antibiotics that were prescribed by antibiotics were revealed. Eight times more likely to develop sepsis.

After two years, 1.6% of patients receiving antibiotics died in almost 60 days. This means that in the epizentro there was a double risk of delaying the risk of mortality (16%) among patients with delayed antibiotic, while antibiotics did not double the risk of patients.

According to the researchers, on average, with 37 antibiotic patients with deferred antibiotics and 51 antibiotics, a sequence-free case would not happen with antibiotics.

Likewise, the hospital admission rate has doubled (27%), in patients with over-the-counter or delayed prescriptions, compared to those who receive special prescriptions (15%).

Older people, especially those over 85 years of age, and those living in lesser areas are at risk.

Researchers have stressed that only antibiotics that detect this study reveal the risk of sepsis and death, rather than directly affecting it. Patients had other health conditions that could not be taken care of by the researchers, which could cause sepsis or death to increase.

Lead author Dr Myriam Gharbi, Imperial School of Public Health, said: "Today's GP GPs recommend national regulations for their symptoms to ask for patients with seriousness, to discuss possible self-care, such as drinking lots of water to prevent dehydration and to prevent paracetamol or ibuprofen To take pain relief and to take antibiotic prescription protection measures should be taken if symptoms have not been worsened or improved after 48 hours. This is to prevent excess antibiotic use, sometimes UTIs can get better without medication. However, our research suggests antibiotics delaying elderly patients It is not ".

Scientists also analyzed data from 157, 264 patients, 65 years of age or older, UTI or suspect UTI, to clarify what the antibiotic dictates. According to data from the Catalan Data Path Research Unit, Datalink uses anonymous patient data from GP practices related to hospital data and allows patients to monitor between two settings. The average age of patients in the study was 77 years.

Professor Paul Aylin, the author of the Imperial NIHR Healthcare Research Unit, said: "Although antibiotic prescription can be monitored for antibiotic resistance, early antibiotics suggest the UTI's most vulnerable to early-stage antibiotics."

In English, Professor of Public Health, Alan Johnson, undertook research: "Antibiotics is one of the main threats to public health that exacerbates the use of antibiotic resistance. Current recommendations include health professionals to consider antibiotics to prescribe whether or not to prescribe antibiotics for a patient with suspected infections of liver disease. ".

"This study takes into account the importance of taking age as a means to reduce the risk of complications when making prescription for antibiotics, which will help the physician to improve the use of antibiotics more effectively and improve the welfare of the patient."

The research is published in the BMJ journal.

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