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Important progress! Studies finds a new drug in the fight against malaria



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The study found a new weapon against malaria & nbsp | & nbspPhoto Credit: & nbspAFP

Over the years, insecticide crushed mosquitoes have been able to significantly reduce malaria infections, but have found alternative insecticide resistance and a new investigation. The weapon is known: human beings have already used anti-malaria drugs to prevent hospitalization, and now they expect researchers to use them in the form of insecticides.

The research shows mosquito dysfunction, prevent malaria parasitic from killing and transmitting insects. In 2016, 435,000 people were killed as a major breakthrough in the fight against a disease, most of them in Africa less than five years old.

In 2017, the number of cases of malaria increased to 219 million, a sign that reverses the rise of the previous year and reverses the long-term progress. Researchers, including Flaminia Catteruccia, Professor of Immunology and Infectious Diseases at Harvard University, have found that the mosquitoes against anti-malaria atoll or the small doses called ATQ were "a complete parasitic arrest".

"We have tried a couple of anti-malarias and we've worked with ATQ: all the parasites have been killed!" Catteruccia told AFP by email.

Attack from the mosquito inside

Initially, the insecticide resistance developed to prevent the spread of mosquitoes in the form of sterilization. But it was demonstrated that when the compounds discovered that diseases had damaged malaria parasitic, the focus was changed.

"We thought afterwards that in order to attack them with non-parasitic chemicals, why not kill the most effective anti-malaria," said Catterucci.

They are located on the ATQ, like insecticides, because they penetrate the meshes to the nets that put them in the net. On Thursday, the group that published the journal Nature magazine wanted to simulate the conditions that insects put on the networks.

Two patients were fed with malaria infected with the blood and then suffered a group with ATQ coated surfaces. The contact with the surface six minutes before – the insects tried to bury the bite at a time when it was used on the net, the malaria parasites were cleaned in mosques.

However, mosquitoes in the control groups did not show the prevalence and intensity of the "malaria" infection of the ATQ. While drug abuse prevented the recruitment of malaria parasites, insects contacted 24 hours before they started eating the infected blood.

The researchers showed computer modeling that their novel approach would "significantly affect the effects of global resistance against insecticides" in the fight against malaria.

Significant barriers

"We are very pleased that this new idea helps fight against malaria because it is safe for people who respect these networks and environmentally friendly," said Catterucciak.

But the researchers acknowledge that significant work is needed in order to use anti-malaria directly against mosquitoes, and there are risks.

Mosquitos does not develop ATQ resistance to survive or play, but malaria parasites "are always at risk of endangerment," said Catterucci.

The vision of ATQ resistance against juggling is particularly problematic, since the disease is a key factor in human treatment. To address this problem, researchers are proposing the investigation of other drugs to kill malaria parasite in different ways.

"We can reduce the chance of drug-resistance emergence using different drugs in humans and mosquitoes," said Catteruccia.

The team must also analyze the cost of drug use, and it would be stable in the time that the network was exposed. Long-term international approval will be long, Janet Hemingway, Professor of Vector Biology at the Liverpool School of Tropical Medicine.

"It is obvious that obstacles must be overcome prior to the creation of produced products to be used by founder, country, and community control programs", wrote in a revised study by Nature.

Additionally, other factors include increasing the number of malaria infections, including experts, reduction of infection campaigns and the use of insecticide-treated networks.


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