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Researchers have found a mechanism that regulates telomeres



Telomers (green) are in the chromosome counts (red). Credit: Jose Escandell, IGC

The advice of the chromosome is telomeres, structures that are similar to plastic roofs at the end of the shoelaces. They act as protective diseases to prevent and advance genetic material. If the telomere are not functioning properly, the total erosion of genetic material can occur, which causes cancer and early illness. Now published in a study EMBO MagazineA research team from the Instituto Gulbenkian de Ciência (IGC), José Escandell and Miguel Godinho Ferreira has rewritten the key aspects of telomere regulation.


Syndrome can be attributed to the poor functioning of human telomeres. One of these diseases was caused by the malfunction of a protein complex called CST, keeping telomeres. The shortcomings of this complexity are called the Coats Plus telomeropathy. Syndrome is inherited genetically and contains anomalies of the gastrointestinal system, bones, brain and other parts of the body. The IGC researchers are now reviewing details of the components of the "S" component of this complex CST. Researchers have found that STN1 (protein component S) regulates a chemical modification of the phosphorus of this protein, and an enzyme can change the phosphatase SSU72. This process allows regulating the telomere dubbing and telomerase, enzymes that stretch telomeres.

Researchers have also shown that this process is the same in both yeast and human cells. This means that the regulation of the "S" component is maintained during the evolution of the species, which demonstrates the importance of the process for the proper functioning of the cell.

The discovery opens new avenues for diseases related to telomeres. "The predicted role of this evolutionary phosphorylate evokes the regulation of the cell cycle, phosphatases that save kinasa role, only once in the cell cycle," says researcher Miguel Godinho Ferreira. "With this work, we understand better how telomeres regulation works, the key to cancer and aging," says José Escandell, the first publisher.


Explore more:
Blending the two enzymes can cause cancer cells to die

More information:
Jose Miguel Escandell et al. Ssu72 is a term for a telomere replication that is conserved with phosphatase, EMBO Magazine (2019). DOI: 10.15252 / embj.2018100476

Magazine reference:
EMBO Magazine

Given:
Gulbenkian Institute of Science (IGC)


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