Nov 29, 2018, 4:09 PM IST
New York: Researchers found that minocycle antibiotics can increase the lifestyle of spinal kittens by preventing the extraction of proteins, which reveal protective mechanisms that can help protect older neurodegenerative diseases in humans.
Protein aggregation has created several progressive brain diseases such as amyotrophic lateral sclerosis, Alzheimer's, Parkinson's disease and prion disease.
A research study conducted by Scripps Research in the United States has shown that minocycline inhibits this construction with elderly animals, through stress and response pathways.
The number of proteins in a cell depends on the manufacturing and availability of proteins called proteostasis. As an age, the damage to proteostasis decreases.
"We have identified the minocycline to stretch the lifespan and improve the protein balance already with alcohol worms," said Michael Petrascheck, associate professor of Scripps Research.
"Our research shows how to inhibit minocycline protein aggregation and a series of neurodegenerative diseases that optimize this drug already approved based on drug development efforts."
For the study, when reviewed in the eLife journal, the team tested the 21 young and old cells 21 cells, known as Caenorhabditis elegans (C. elegans) for the first time.
All of these molecules extended the life of young worms; However, the only drug used by older worms was the minocycline.
To find out, old and young worms were treated with water or minocycline and subsequently developed a synuclein and amyloid-like proteins in Parkinson's and Alzheimer's diseases, respectively.
Considering the age of the worms, the treated minocyclines reduced the integration of both proteins, although they did not activate the stress response.
Minocycline directly affects the cellular protein manufacturing machines, known as ribosomes. Worms and mice and human cells were true, researchers said.