As a result of the disappearance of the polio-polio virus, only 22 people were hired in 2017. He is out of work, but most of the challenges facing the need for a vaccine are at risk of extinguishing the pulmonary virus.
Lastly, finally, thanks to a new method to improve the shape of the optimal form of the vaccine, this new method does not require refrigeration.
As a powdery freeze powder, the vaccine can now be displaced to undocumented areas, which can give too little immunity to this destructive illness from endangered populations.
Scientists from the University of South California worked with researchers at Integrity Bio to develop a process that eliminates the development of poliovirus deactivated vaccine (IPV) without improving their stability to improve their temperature stability.
"However, no matter how wonderful a drug or vaccine is, if it is not a stable carrier, it does not make anyone very good," says the first Woo-Jin Shin studio.
Polio vaccines are collected twice. The first one was developed by Jonas Salk in the 1950s and involves the injection of poliovirus particles.
Albert Sabin was the second method developed in the second decade of the Russian medical researcher. Although it does not have a needle, the oral oral vaccine is easily recycled in a straightforward and weak way, and it is at risk of catching the disease.
This risk was not great. Only 96 cases of bacterial anti-inflammation in 2017 appeared, and the possibilities with virulent virus symptoms are also very small.
We still did it without danger. Therefore, the Global Polio Eradication Initiation completely eliminates the injected vaccine.
Using IPV is probably not insecurity, but as with most biological materials, lights, temperatures and other environmental conditions make short proteins, which are useless when inoculating against a disease.
In a 2 to 8-degree center (35-46 Fahrenheit), IPV paths can be maintained for up to four years. Otherwise, they go on a summer day as a fish.
The vaccine component helps to dry the frozen ones, a method used to place a lot of time, including alcohol, typhoid and meningococcal disease.
But the IPV dehydrator has proved more challenging, at a higher temperature than impressive stability.
Finding a new process is not difficult. At least not in principle.
"Stabilization is not rocket science, so most academics do not pay much attention in this area," says Shin.
It is difficult to find out that these methods are the potential winners and the potential of the vaccine to become an efficient potentially pile of powders.
In this way, the team invented a new initial assessment, following the preparation of its BPN power determination.
Thus, if they go through various formulations for freezing drying, using high-performance liquid chromatography should continue to work their magic.
The result was five days in a row to keep 37 degrees centimeters (99 degrees Fahrenheit) at a temperature of 4 degrees Fahrenheit (39 degrees).
Testing the mice, the rehydrated form of the vaccine gave the same level of immunity.
The disease of polio may be the most repulsive for forgiveness, because thinking is already gone. Since 1979, it has not been registered in the U.S.
Before the immunization, the cases of the year could be a rise of 60,000. Among the adults with paralytic form of the disease, almost three months before death.
There are three tensions of the pulmonary virus. One officially declared for 2015, after 16 years it was detected throughout India. Another has not been seen since 2012
However, it leaves a variety of varieties that remain in Pakistani and Afghan communities. In fact, we have to finish it and avoiding the return of these epidemics, we must overcome all the obstacles.
The world needs this vaccine to finish the job.
This study was published mbio.